EMT-Related Genes Have No Prognostic Relevance in Metastatic Colorectal Cancer as Opposed to Stage II/III: Analysis of the Randomised, Phase III Trial FIRE-3

Despite huge advances in local and systemic therapies, the 5-year relative survival rate for patients with metastatic CRC is still low. To avoid over- or undertreatment, proper risk stratification with regard to treatment strategy is highly needed. As EMT (epithelial-mesenchymal transition) is a maj...

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Bibliographic Details
Published in:Cancers 2022, Vol.14 (22)
Main Authors: Pretzsch, Elise, Heinemann, Volker, Stintzing, Sebastian, Bender, Andreas, Chen, Shuo, Holch, Julian Walter, Hofmann, Felix Oliver, Ren, Haoyu, Bösch, Florian, Küchenhoff, Helmut, Werner, Jens, Angele, Martin Konrad
Format: Report
Language:English
Online Access:Get full text
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Summary:Despite huge advances in local and systemic therapies, the 5-year relative survival rate for patients with metastatic CRC is still low. To avoid over- or undertreatment, proper risk stratification with regard to treatment strategy is highly needed. As EMT (epithelial-mesenchymal transition) is a major step in metastatic spread, this study analysed the prognostic effect of EMT-related genes in stage IV colorectal cancer patients using the study cohort of the FIRE-3 trial, an open-label multi-centre randomised controlled phase III trial of stage IV colorectal cancer patients. Overall, the prognostic relevance of EMT-related genes seems stage-dependent. EMT-related genes have no prognostic relevance in stage IV CRC as opposed to stage II/III.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers14225596