EMT-Related Genes Have No Prognostic Relevance in Metastatic Colorectal Cancer as Opposed to Stage II/III: Analysis of the Randomised, Phase III Trial FIRE-3

Despite huge advances in local and systemic therapies, the 5-year relative survival rate for patients with metastatic CRC is still low. To avoid over- or undertreatment, proper risk stratification with regard to treatment strategy is highly needed. As EMT (epithelial-mesenchymal transition) is a maj...

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Published in:Cancers 2022, Vol.14 (22)
Main Authors: Pretzsch, Elise, Heinemann, Volker, Stintzing, Sebastian, Bender, Andreas, Chen, Shuo, Holch, Julian Walter, Hofmann, Felix Oliver, Ren, Haoyu, Bösch, Florian, Küchenhoff, Helmut, Werner, Jens, Angele, Martin Konrad
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container_issue 22
container_start_page
container_title Cancers
container_volume 14
creator Pretzsch, Elise
Heinemann, Volker
Stintzing, Sebastian
Bender, Andreas
Chen, Shuo
Holch, Julian Walter
Hofmann, Felix Oliver
Ren, Haoyu
Bösch, Florian
Küchenhoff, Helmut
Werner, Jens
Angele, Martin Konrad
description Despite huge advances in local and systemic therapies, the 5-year relative survival rate for patients with metastatic CRC is still low. To avoid over- or undertreatment, proper risk stratification with regard to treatment strategy is highly needed. As EMT (epithelial-mesenchymal transition) is a major step in metastatic spread, this study analysed the prognostic effect of EMT-related genes in stage IV colorectal cancer patients using the study cohort of the FIRE-3 trial, an open-label multi-centre randomised controlled phase III trial of stage IV colorectal cancer patients. Overall, the prognostic relevance of EMT-related genes seems stage-dependent. EMT-related genes have no prognostic relevance in stage IV CRC as opposed to stage II/III.
doi_str_mv 10.3390/cancers14225596
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title EMT-Related Genes Have No Prognostic Relevance in Metastatic Colorectal Cancer as Opposed to Stage II/III: Analysis of the Randomised, Phase III Trial FIRE-3
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