The IDrosophila simulans/I Genome Lacks the Icrystal/I-IStellate/I System

The cry-Ste system is a genetic interaction system between heterochromatin and euchromatin in Drosophila melanogaster, regulated via the piRNA pathway. Deregulation of this system leads to meiotic defects and male sterility. Although the cry-Ste system is peculiar to D. melanogaster, ancestors of St...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2022-11, Vol.11 (23)
Main Authors: De Grassi, Anna, Tritto, Patrizia, Palumbo, Valeria, Bozzetti, Maria Pia, Berloco, Maria Francesca
Format: Article
Language:English
Subjects:
Drosophila
Genetic aspects
Genetic research
Genomes
Online Access:Get full text
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Summary:The cry-Ste system is a genetic interaction system between heterochromatin and euchromatin in Drosophila melanogaster, regulated via the piRNA pathway. Deregulation of this system leads to meiotic defects and male sterility. Although the cry-Ste system is peculiar to D. melanogaster, ancestors of Ste and Su(Ste) elements are present in the three closely related species, D. simulans, D. sechellia, and D. mauritiana. The birth, evolution, and maintenance of this genetic system in Drosophila melanogaster are of interest. We investigate the presence of sequences homologous to cry and Ste elements in the simulans complex and describe their chromosomal distribution. The organization and expression of cry- and Ste-like sequences were further characterized in the D. simulans genome. Our results allow us to conclude that the cry-Ste genetic interaction system is absent in the D. simulans genome.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells11233725