Biomineral nanocomposite scaffold carrier for improved stability of vitamin D.sub.3: characterization analysis and material properties

A powdered PVA/CaCO.sub.3 nanocomposite carrier was successfully fabricated for effective loading of small bioactive molecules, such as vitamin D.sub.3 (VD.sub.3). Generation of, namely, VD.sub.3/PVA/CaCO.sub.3 nanocomposite scaffold was carried out through an adsorption mechanism as a loading route...

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Bibliographic Details
Published in:Journal of materials science 2023-04, Vol.58 (15), p.6580
Main Authors: Jankovic, Bojan, Papovic, Snezana, Vranes, Milan, Knezevic, Teodora, Przulj, Sanja, Zeljkovic, Sasa, Velickovic, Suzana
Format: Article
Language:English
Subjects:
Adsorption
Analysis
Calcite crystals
Carbonates
Density functionals
Diffraction
Ionization
Mass spectrometry
Vitamins
X-rays
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Summary:A powdered PVA/CaCO.sub.3 nanocomposite carrier was successfully fabricated for effective loading of small bioactive molecules, such as vitamin D.sub.3 (VD.sub.3). Generation of, namely, VD.sub.3/PVA/CaCO.sub.3 nanocomposite scaffold was carried out through an adsorption mechanism as a loading route of an active compound onto a powder carrier. Developed composites were characterized by structural, morphological and thermal analyses techniques, such as X-ray powder diffraction (XRPD), Fourier-transform infrared (FTIR) spectroscopy, MALDI (matrix-assisted laser desorption/ionization) - mass spectrometry (MS), Brunauer-Emmett-Teller (BET) - NLDFT (Non-local Density Functional Theory) method, scanning electron microscopy (SEM), simultaneous TG-DTG and coupled TG-MS. XRD results showed that the average crystallite size of synthesized VD.sub.3/PVA/CaCO.sub.3 amounts 32.93 nm exhibiting microstrain presence, where PVA incorporation causes non-uniform calcite lattice distortion. SEM analysis showed that VD.sub.3/PVA/CaCO.sub.3 nanocomposite scaffold contains agglomerated rhomboidal calcite particles with VD.sub.3 particles of irregular shapes attached. Fabricated VD.sub.3/PVA/CaCO.sub.3 clearly showed the existence of calcite "staircase" dendrites as the aftermath of inhibiting the effect of impurities on the growth of crystals in normal directions. It was determined that the decomposition of PVA additionally enhances the thermal stability of VD.sub.3, through the stabilization effect by acting on van der Waal's forces during polyene formation, confirmed by MALDI-TOF MS results.
ISSN:0022-2461
DOI:10.1007/s10853-023-08453-z