New Azido Coumarins as Potential Agents for Fluorescent Labeling and Their “Click” Chemistry Reactions for the Conjugation with Icloso/I-Dodecaborate Anion

Novel fluorescent 7-methoxy- and 7-(diethylamino)-coumarins modified with azido-group on the side chain have been synthesized. Their photophysical properties and single crystals structure characteristics have been studied. In order to demonstrate the possibilities of fluorescent labeling, obtained c...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2022-12, Vol.27 (23)
Main Authors: Laskova, Julia, Serdyukov, Alexander, Kosenko, Irina, Ananyev, Ivan, Titova, Ekaterina, Druzina, Anna, Sivaev, Igor, Antonets, Anastasia A, Nazarov, Alexey A, Bregadze, Vladimir I
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Language:English
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Cells
Coumarins
Labeling
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container_issue 23
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container_title Molecules (Basel, Switzerland)
container_volume 27
creator Laskova, Julia
Serdyukov, Alexander
Kosenko, Irina
Ananyev, Ivan
Titova, Ekaterina
Druzina, Anna
Sivaev, Igor
Antonets, Anastasia A
Nazarov, Alexey A
Bregadze, Vladimir I
description Novel fluorescent 7-methoxy- and 7-(diethylamino)-coumarins modified with azido-group on the side chain have been synthesized. Their photophysical properties and single crystals structure characteristics have been studied. In order to demonstrate the possibilities of fluorescent labeling, obtained coumarins have been tested with closo-dodecaborate derivative bearing terminal alkynyl group. Cu[sup.I] catalyzed Huisgen 1,3-dipolar cycloaddition reaction has led to fluorescent conjugates formation. The absorption-emission spectra of the formed conjugates have been presented. The antiproliferative activity and uptake of compounds against several human cell lines were evaluated.
doi_str_mv 10.3390/molecules27238575
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subjects Cells
Coumarins
Labeling
title New Azido Coumarins as Potential Agents for Fluorescent Labeling and Their “Click” Chemistry Reactions for the Conjugation with Icloso/I-Dodecaborate Anion
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