Sarcoconvolutums F and G: Polyoxygenated Cembrane-Type Diterpenoids from ISarcophyton convolutum/I, a Red Sea Soft Coral

Natural products and chemical analogues are widely used in drug discovery, notably in cancer and infectious disease pharmacotherapy. Sarcophyton convolutum (Alcyoniidae) a Red Sea–derived soft coral has been shown to be a rich source of macrocyclic diterpenes and cyclized derivatives. Two previously...

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Published in:Molecules (Basel, Switzerland) Switzerland), 2022-09, Vol.27 (18)
Main Authors: Mohamed, Tarik A, Elshamy, Abdelsamed I, Abd El-Razek, Mohamed H, Abdel-Tawab, Asmaa M, Ali, Sherin K, Aboelmagd, Mohamed, Suenaga, Midori, Pare, Paul W, Umeyama, Akemi, Hegazy, Mohamed-Elamir F
Format: Article
Language:English
Subjects:
Cancer
Care and treatment
Chemical properties
Diterpenes
Soft corals
Online Access:Get full text
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Summary:Natural products and chemical analogues are widely used in drug discovery, notably in cancer and infectious disease pharmacotherapy. Sarcophyton convolutum (Alcyoniidae) a Red Sea–derived soft coral has been shown to be a rich source of macrocyclic diterpenes and cyclized derivatives. Two previously undescribed polyoxygenated cembrane-type diterpenoids, sarcoconvolutums F (1) and G (2), as well as four identified analogues (3–6) together with a furan derivate (7) were isolated from a solvent extract. Compounds were identified by spectroscopic techniques, including NMR, HREIMS, and CD, together with close spectral comparisons of previously published data. Sarcoconvolutum F (1) contains a rare 1-peroxid-15-hydroxy-10-ene functionality. Isolated metabolites (1–7) were screened against lung adenocarcinoma (A549), cervical cancer (HeLa) and oral cavity carcinoma (HSC-2) lines. Compound 4 exhibited an IC[sub.50] 56 µM and 55 µM against A549 and HSC-2 cells, respectively.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27185835