Antiviral Properties of IPennisetum purpureum/I Extract against Coronaviruses and Enteroviruses

Many severe epidemics are caused by enteroviruses (EVs) and coronaviruses (CoVs), including feline coronavirus (FCoV) in cats, epidemic diarrhea disease virus (PEDV) in pigs, infectious bronchitis virus (IBV) in chickens, and EV71 in human. Vaccines and antiviral drugs are used to prevent and treat...

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Bibliographic Details
Published in:Pathogens (Basel) 2022-11, Vol.11 (11)
Main Authors: Chen, Yi-Ning, Kao, Wenny Mei-Wen, Lee, Shu-Chi, Wu, Jaw-Min, Ho, Yi-Sheng, Hsieh, Ming-Kun
Format: Article
Language:English
Subjects:
Antiviral agents
Cenchrus ciliaris
Chemical properties
Coronavirus infections
Drug therapy
Enterovirus diseases
Health aspects
Materia medica, Vegetable
Pharmaceutical research
Plant extracts
Testing
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Summary:Many severe epidemics are caused by enteroviruses (EVs) and coronaviruses (CoVs), including feline coronavirus (FCoV) in cats, epidemic diarrhea disease virus (PEDV) in pigs, infectious bronchitis virus (IBV) in chickens, and EV71 in human. Vaccines and antiviral drugs are used to prevent and treat the infection of EVs and CoVs, but the effectiveness is affected due to rapidly changing RNA viruses. Many plant extracts have been proven to have antiviral properties despite the continuous mutations of viruses. Napier grass (Pennisetum purpureum) has high phenolic content and has been used as healthy food materials, livestock feed, biofuels, and more. This study tested the antiviral properties of P. purpureum extract against FCoV, PEDV, IBV, and EV71 by in vitro cytotoxicity assay, TCID[sub.50] virus infection assay, and chicken embryo infection assay. The findings showed that P. purpureum extract has the potential of being disinfectant to limit the spread of CoVs and EVs because the extract can inhibit the infection of EV71, FCoV, and PEDV in cells, and significantly reduce the severity of symptoms caused by IBV in chicken embryos.
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens11111371