A Mixture of Kaempferol-3-IO/I-sambubioside and Kaempferol-3-IO/I-sophoroside from IMalvaviscus arboreus/I Prevents Ethanol-Induced Gastric Inflammation, Oxidative Stress, and Histologic Changes

Malvaviscus arboreus is used in traditional Mexican medicine to treat gastrointestinal diseases. Therefore, a mixture of Kaempferol-O-sambubioside and Kaempferol-O-sophoroside (MaSS) isolated from flowers of this species was tested as a preventive treatment on gastric lesions induced with ethanol in...

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Bibliographic Details
Published in:Plants (Basel) 2022-11, Vol.11 (21)
Main Authors: Campos-Vidal, Yrvinn, Zamilpa, Alejandro, Jiménez-Ferrer, Enrique, Jiménez-Aparicio, Antonio Ruperto, Camacho-Díaz, Brenda Hildeliza, Trejo-Tapia, Gabriela, Tapia-Maruri, Daniel, Monterrosas-Brisson, Nayeli, Herrera-Ruiz, Maribel
Format: Article
Language:English
Subjects:
Bioflavonoids
Care and treatment
Flavones
Flavonoids
Gastrointestinal diseases
Testing
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Summary:Malvaviscus arboreus is used in traditional Mexican medicine to treat gastrointestinal diseases. Therefore, a mixture of Kaempferol-O-sambubioside and Kaempferol-O-sophoroside (MaSS) isolated from flowers of this species was tested as a preventive treatment on gastric lesions induced with ethanol in rats. MaSS was obtained by chromatographic methods and administered by oral pathway to male Sprague Dawley rats with ethanol-induced gastric lesions. Pretreatment with MaSS at doses of 30, 90, 120, and 180 mg/kg significantly prevents gastric lesions, inhibits the increment in relative stomach weight (%) in gastric IL-6, and also provokes an increment of IL-10 concentration and catalase activity. Finally, MaSS prevented edema in the mucosa and submucosa and diminished microscopic gastric lesions provoked by ethanol.
ISSN:2223-7747
2223-7747
DOI:10.3390/plants11212951