Predicting Factors Affecting Clinical Pregnancy Rate in Assisted Reproductive Technology

Background: The cryopreserved embryo transfer cycle is regarded as the final critical stage in assisted reproductive technology (ART), with a direct impact on clinical pregnancy rates. Predicting the components in freeze transfer cycles that can improve such results would thus be useful. This study...

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Bibliographic Details
Published in:Iranian journal of medical sciences 2023-01, Vol.48 (S1), p.106
Main Authors: Firoozbad, K. Roustaei, Torshizi, M. Mansuri, Islam, Fadavi, Khalilifar, H
Format: Article
Language:English
Subjects:
Pregnancy
Pregnant women
Prognosis
Reproductive technology
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Summary:Background: The cryopreserved embryo transfer cycle is regarded as the final critical stage in assisted reproductive technology (ART), with a direct impact on clinical pregnancy rates. Predicting the components in freeze transfer cycles that can improve such results would thus be useful. This study aims to assess the factors that influence pregnancy outcomes by comparing the greatest and lowest rates across a year. Methods: This study was conducted in December 2020 (Group 1; with 77 patients) and February 2021 (group 2; with 100 patients) at the Novin Infertility Treatment Center. All the statistical analysis was performed by applying the Student t test and Chi square tests by using SPSS software. Results: Our results show that the clinical pregnancy rate was highest in February (56.4%) and lowest in December (42.9%) (P=0.07). The percentage of embryos with good quality (A+AB grades) was greater in February, at 85.8%, compared to 66.6% in December (P=0.05). Furthermore, patients who underwent embryo transfer in the most successful month had fewer extended cycles (30.4%) than those who had it in the other month (42.4%) (P=0.2). Severe male factor cases were also observed to be higher in group 1 than group 2 (54.9% vs. 45.1%) (P=0.47). There was no statistically significant difference in preparation methods (letrozole or estradiol), RIF and RAB history, frozen-thawed cycle type (cleavage, dual, or blast), or mean maternal age. Conclusion: An increase in the rate of patients with severe male infertility can result in reducing the rate of good-quality embryos, which acts as an underlying factor of a lower clinical pregnancy rate within a month. Moreover, extending FET cycles would seem to be a second parameter affecting outcomes. Keywords * Embryo transfer * Reproductive techniques, assisted * Pregnancy rate * Infertility, male, female
ISSN:0253-0716