Loading…
Dyslipidemia Treatment and Lipid Control in US Adults with Diabetes by Sociodemographic and Cardiovascular Risk Groups in the NIH Precision Medicine Initiative IAll of Us/I Research Program
Real-world data on lipid levels and treatment among adults with diabetes mellitus (DM) are relatively limited. We studied lipid levels and treatment status in patients with DM across cardiovascular disease (CVD) risk groups and sociodemographic factors. In the All of Us Research Program, we categori...
Saved in:
Published in: | Journal of clinical medicine 2023-02, Vol.12 (4) |
---|---|
Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | |
---|---|
cites | |
container_end_page | |
container_issue | 4 |
container_start_page | |
container_title | Journal of clinical medicine |
container_volume | 12 |
creator | Akbarpour, Meleeka Devineni, Divya Gong, Yufan Wong, Nathan D |
description | Real-world data on lipid levels and treatment among adults with diabetes mellitus (DM) are relatively limited. We studied lipid levels and treatment status in patients with DM across cardiovascular disease (CVD) risk groups and sociodemographic factors. In the All of Us Research Program, we categorized DM as (1) moderate risk (≤1 CVD risk factor), (2) high risk (≥2 CVD risk factors), and (3) DM with atherosclerotic CVD (ASCVD). We examined the use of statin and non-statin therapy as well as LDL-C and triglyceride levels. We studied 81,332 participants with DM, which included 22.3% non-Hispanic Black and 17.2% Hispanic. A total of 31.1% had ≤1 DM risk factor, 30.3% had ≥2 DM risk factors, and 38.6% of participants had DM with ASCVD. Only 18.2% of those with DM and ASCVD were on high-intensity statins. Overall, 5.1% were using ezetimibe and 0.6% PCSK9 inhibitors. Among those with DM and ASCVD, only 21.1% had LDL-C < 70 mg/dL. Overall, 1.9% of participants with triglycerides ≥ 150 mg/dL were on icosapent ethyl. Those with DM and ASCVD were more likely to be on high-intensity statins, ezetimibe, and icosapent ethyl. Guideline-recommended use of high-intensity statins and non-statin therapy among our higher risk DM patients is lacking, with LDL-C inadequately controlled. |
doi_str_mv | 10.3390/jcm12041668 |
format | article |
fullrecord | <record><control><sourceid>gale</sourceid><recordid>TN_cdi_gale_infotracmisc_A750334978</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A750334978</galeid><sourcerecordid>A750334978</sourcerecordid><originalsourceid>FETCH-LOGICAL-g678-925a4f2b78c51055460047328d25efc25b05f65a2722716efaab2c21a376a74e3</originalsourceid><addsrcrecordid>eNptkM1O6zAQhSMEEojLihcYiXXBseM4XVblr1K5IChrNHEm7UBiV7YL4uF4N1JgwYKZxRyNzvlGmiw7zsWpUmNx9mz7XIoiL8tqJzuQwpiRUJXa_aX3s6MYn8VQVVXI3BxkH-fvseM1N9QzwiIQpp5cAnQNzLd7mHqXgu-AHTw-wKTZdCnCG6cVnDPWlChC_Q4P3rIfIH4ZcL1i-wWYYmjYv2K0mw4D3HN8gavgN-u4paUVwf_ZNdwFshzZO7ihhi07gpnjxJj4dZCTrgPfwmM8m8E9RcJgV0Nme6j_l-212EU6-pmH2eLyYjG9Hs1vr2bTyXy0LE01GkuNRStrU1mdC62LUojCKFk1UlNrpa6FbkuN0khp8pJaxFpamaMyJZqC1GF28o1dYkdP7FqfAtqeo32aGC2UKsamGlynf7iG3v7WekctD_tfgU_lmIZX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Dyslipidemia Treatment and Lipid Control in US Adults with Diabetes by Sociodemographic and Cardiovascular Risk Groups in the NIH Precision Medicine Initiative IAll of Us/I Research Program</title><source>Publicly Available Content Database</source><source>PubMed Central(OpenAccess)</source><creator>Akbarpour, Meleeka ; Devineni, Divya ; Gong, Yufan ; Wong, Nathan D</creator><creatorcontrib>Akbarpour, Meleeka ; Devineni, Divya ; Gong, Yufan ; Wong, Nathan D</creatorcontrib><description>Real-world data on lipid levels and treatment among adults with diabetes mellitus (DM) are relatively limited. We studied lipid levels and treatment status in patients with DM across cardiovascular disease (CVD) risk groups and sociodemographic factors. In the All of Us Research Program, we categorized DM as (1) moderate risk (≤1 CVD risk factor), (2) high risk (≥2 CVD risk factors), and (3) DM with atherosclerotic CVD (ASCVD). We examined the use of statin and non-statin therapy as well as LDL-C and triglyceride levels. We studied 81,332 participants with DM, which included 22.3% non-Hispanic Black and 17.2% Hispanic. A total of 31.1% had ≤1 DM risk factor, 30.3% had ≥2 DM risk factors, and 38.6% of participants had DM with ASCVD. Only 18.2% of those with DM and ASCVD were on high-intensity statins. Overall, 5.1% were using ezetimibe and 0.6% PCSK9 inhibitors. Among those with DM and ASCVD, only 21.1% had LDL-C < 70 mg/dL. Overall, 1.9% of participants with triglycerides ≥ 150 mg/dL were on icosapent ethyl. Those with DM and ASCVD were more likely to be on high-intensity statins, ezetimibe, and icosapent ethyl. Guideline-recommended use of high-intensity statins and non-statin therapy among our higher risk DM patients is lacking, with LDL-C inadequately controlled.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm12041668</identifier><language>eng</language><publisher>MDPI AG</publisher><subject>Cardiovascular diseases ; Care and treatment ; Complications and side effects ; Demographic aspects ; Diabetes ; Dyslipidemias ; Risk factors</subject><ispartof>Journal of clinical medicine, 2023-02, Vol.12 (4)</ispartof><rights>COPYRIGHT 2023 MDPI AG</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Akbarpour, Meleeka</creatorcontrib><creatorcontrib>Devineni, Divya</creatorcontrib><creatorcontrib>Gong, Yufan</creatorcontrib><creatorcontrib>Wong, Nathan D</creatorcontrib><title>Dyslipidemia Treatment and Lipid Control in US Adults with Diabetes by Sociodemographic and Cardiovascular Risk Groups in the NIH Precision Medicine Initiative IAll of Us/I Research Program</title><title>Journal of clinical medicine</title><description>Real-world data on lipid levels and treatment among adults with diabetes mellitus (DM) are relatively limited. We studied lipid levels and treatment status in patients with DM across cardiovascular disease (CVD) risk groups and sociodemographic factors. In the All of Us Research Program, we categorized DM as (1) moderate risk (≤1 CVD risk factor), (2) high risk (≥2 CVD risk factors), and (3) DM with atherosclerotic CVD (ASCVD). We examined the use of statin and non-statin therapy as well as LDL-C and triglyceride levels. We studied 81,332 participants with DM, which included 22.3% non-Hispanic Black and 17.2% Hispanic. A total of 31.1% had ≤1 DM risk factor, 30.3% had ≥2 DM risk factors, and 38.6% of participants had DM with ASCVD. Only 18.2% of those with DM and ASCVD were on high-intensity statins. Overall, 5.1% were using ezetimibe and 0.6% PCSK9 inhibitors. Among those with DM and ASCVD, only 21.1% had LDL-C < 70 mg/dL. Overall, 1.9% of participants with triglycerides ≥ 150 mg/dL were on icosapent ethyl. Those with DM and ASCVD were more likely to be on high-intensity statins, ezetimibe, and icosapent ethyl. Guideline-recommended use of high-intensity statins and non-statin therapy among our higher risk DM patients is lacking, with LDL-C inadequately controlled.</description><subject>Cardiovascular diseases</subject><subject>Care and treatment</subject><subject>Complications and side effects</subject><subject>Demographic aspects</subject><subject>Diabetes</subject><subject>Dyslipidemias</subject><subject>Risk factors</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptkM1O6zAQhSMEEojLihcYiXXBseM4XVblr1K5IChrNHEm7UBiV7YL4uF4N1JgwYKZxRyNzvlGmiw7zsWpUmNx9mz7XIoiL8tqJzuQwpiRUJXa_aX3s6MYn8VQVVXI3BxkH-fvseM1N9QzwiIQpp5cAnQNzLd7mHqXgu-AHTw-wKTZdCnCG6cVnDPWlChC_Q4P3rIfIH4ZcL1i-wWYYmjYv2K0mw4D3HN8gavgN-u4paUVwf_ZNdwFshzZO7ihhi07gpnjxJj4dZCTrgPfwmM8m8E9RcJgV0Nme6j_l-212EU6-pmH2eLyYjG9Hs1vr2bTyXy0LE01GkuNRStrU1mdC62LUojCKFk1UlNrpa6FbkuN0khp8pJaxFpamaMyJZqC1GF28o1dYkdP7FqfAtqeo32aGC2UKsamGlynf7iG3v7WekctD_tfgU_lmIZX</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Akbarpour, Meleeka</creator><creator>Devineni, Divya</creator><creator>Gong, Yufan</creator><creator>Wong, Nathan D</creator><general>MDPI AG</general><scope/></search><sort><creationdate>20230201</creationdate><title>Dyslipidemia Treatment and Lipid Control in US Adults with Diabetes by Sociodemographic and Cardiovascular Risk Groups in the NIH Precision Medicine Initiative IAll of Us/I Research Program</title><author>Akbarpour, Meleeka ; Devineni, Divya ; Gong, Yufan ; Wong, Nathan D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g678-925a4f2b78c51055460047328d25efc25b05f65a2722716efaab2c21a376a74e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cardiovascular diseases</topic><topic>Care and treatment</topic><topic>Complications and side effects</topic><topic>Demographic aspects</topic><topic>Diabetes</topic><topic>Dyslipidemias</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akbarpour, Meleeka</creatorcontrib><creatorcontrib>Devineni, Divya</creatorcontrib><creatorcontrib>Gong, Yufan</creatorcontrib><creatorcontrib>Wong, Nathan D</creatorcontrib><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akbarpour, Meleeka</au><au>Devineni, Divya</au><au>Gong, Yufan</au><au>Wong, Nathan D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dyslipidemia Treatment and Lipid Control in US Adults with Diabetes by Sociodemographic and Cardiovascular Risk Groups in the NIH Precision Medicine Initiative IAll of Us/I Research Program</atitle><jtitle>Journal of clinical medicine</jtitle><date>2023-02-01</date><risdate>2023</risdate><volume>12</volume><issue>4</issue><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Real-world data on lipid levels and treatment among adults with diabetes mellitus (DM) are relatively limited. We studied lipid levels and treatment status in patients with DM across cardiovascular disease (CVD) risk groups and sociodemographic factors. In the All of Us Research Program, we categorized DM as (1) moderate risk (≤1 CVD risk factor), (2) high risk (≥2 CVD risk factors), and (3) DM with atherosclerotic CVD (ASCVD). We examined the use of statin and non-statin therapy as well as LDL-C and triglyceride levels. We studied 81,332 participants with DM, which included 22.3% non-Hispanic Black and 17.2% Hispanic. A total of 31.1% had ≤1 DM risk factor, 30.3% had ≥2 DM risk factors, and 38.6% of participants had DM with ASCVD. Only 18.2% of those with DM and ASCVD were on high-intensity statins. Overall, 5.1% were using ezetimibe and 0.6% PCSK9 inhibitors. Among those with DM and ASCVD, only 21.1% had LDL-C < 70 mg/dL. Overall, 1.9% of participants with triglycerides ≥ 150 mg/dL were on icosapent ethyl. Those with DM and ASCVD were more likely to be on high-intensity statins, ezetimibe, and icosapent ethyl. Guideline-recommended use of high-intensity statins and non-statin therapy among our higher risk DM patients is lacking, with LDL-C inadequately controlled.</abstract><pub>MDPI AG</pub><doi>10.3390/jcm12041668</doi></addata></record> |
fulltext | fulltext |
identifier | ISSN: 2077-0383 |
ispartof | Journal of clinical medicine, 2023-02, Vol.12 (4) |
issn | 2077-0383 2077-0383 |
language | eng |
recordid | cdi_gale_infotracmisc_A750334978 |
source | Publicly Available Content Database; PubMed Central(OpenAccess) |
subjects | Cardiovascular diseases Care and treatment Complications and side effects Demographic aspects Diabetes Dyslipidemias Risk factors |
title | Dyslipidemia Treatment and Lipid Control in US Adults with Diabetes by Sociodemographic and Cardiovascular Risk Groups in the NIH Precision Medicine Initiative IAll of Us/I Research Program |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T02%3A53%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dyslipidemia%20Treatment%20and%20Lipid%20Control%20in%20US%20Adults%20with%20Diabetes%20by%20Sociodemographic%20and%20Cardiovascular%20Risk%20Groups%20in%20the%20NIH%20Precision%20Medicine%20Initiative%20IAll%20of%20Us/I%20Research%20Program&rft.jtitle=Journal%20of%20clinical%20medicine&rft.au=Akbarpour,%20Meleeka&rft.date=2023-02-01&rft.volume=12&rft.issue=4&rft.issn=2077-0383&rft.eissn=2077-0383&rft_id=info:doi/10.3390/jcm12041668&rft_dat=%3Cgale%3EA750334978%3C/gale%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-g678-925a4f2b78c51055460047328d25efc25b05f65a2722716efaab2c21a376a74e3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rft_galeid=A750334978&rfr_iscdi=true |