New Anti-Hypoxic Metabolites from Co-Culture of Marine-Derived Fungi IAspergillus carneus/I KMM 4638 and IAmphichorda/I sp. KMM 4639

The KMM 4639 strain was identified as Amphichorda sp. based on two molecular genetic markers: ITS and β-tubulin regions. Chemical investigation of co-culture marine-derived fungi Amphichorda sp. KMM 4639 and Aspergillus carneus KMM 4638 led to the identification of five new quinazolinone alkaloids f...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2023-04, Vol.13 (5)
Main Authors: Belousova, Elena B, Zhuravleva, Olesya I, Yurchenko, Ekaterina A, Oleynikova, Galina K, Antonov, Alexandr S, Kirichuk, Natalya N, Chausova, Viktoria E, Khudyakova, Yuliya V, Menshov, Alexander S, Popov, Roman S, Menchinskaya, Ekaterina S, Pislyagin, Evgeny A, Mikhailov, Valery V, Yurchenko, Anton N
Format: Article
Language:English
Subjects:
Ascomycota
Aspergillus
Chemical properties
Fungi
Genetic aspects
Identification and classification
Metabolites
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Summary:The KMM 4639 strain was identified as Amphichorda sp. based on two molecular genetic markers: ITS and β-tubulin regions. Chemical investigation of co-culture marine-derived fungi Amphichorda sp. KMM 4639 and Aspergillus carneus KMM 4638 led to the identification of five new quinazolinone alkaloids felicarnezolines A–E (1–5), a new highly oxygenated chromene derivative oxirapentyn M (6) and five previously reported related compounds. Their structures were established using spectroscopic methods and by comparison with related known compounds. The isolated compounds showed low cytotoxicity against human prostate and breast cancer cells but felicarnezoline B (2) protected rat cardiomyocytes H9c2 and human neuroblastoma SH-SY5Y cells against CoCl[sub.2] -induced damage.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom13050741