The Related Mechanisms Predicted through Network-Based Pharmacological Analysis and the Anti-Inflammatory Effects of IFraxinus rhynchophylla/I Hance Bark on Contact Dermatitis in Mice

Fraxinus rhynchophylla Hance bark has been used to treat patients with inflammatory or purulent skin diseases in China, Japan, and Korea. This study was undertaken to determine the mechanism responsible for the effects of F. rhynchophylla and whether it has a therapeutic effect in mice with contact...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-03, Vol.24 (7)
Main Authors: Kim, Sura, Lyu, Ji-Hyo, Yang, Beodeul, Kim, Soyeon, Kim, Jung-Hoon, Kim, Hyungwoo, Cho, Suin
Format: Article
Language:English
Subjects:
Analysis
Anti-inflammatory drugs
B cells
Contact dermatitis
Health aspects
Kim, Soyeon
Skin
Online Access:Get full text
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Summary:Fraxinus rhynchophylla Hance bark has been used to treat patients with inflammatory or purulent skin diseases in China, Japan, and Korea. This study was undertaken to determine the mechanism responsible for the effects of F. rhynchophylla and whether it has a therapeutic effect in mice with contact dermatitis (CD). In this study, the active compounds in F. rhynchophylla, their targets, and target gene information for inflammatory dermatosis were investigated using network-based pharmacological analysis. Docking analysis was conducted using AutoDock Vina. In addition, the therapeutic effect of an ethanolic extract of F. rhynchophylla (EEFR) on skin lesions and its inhibitory effects on histopathological abnormalities, inflammatory cytokines, and chemokines were evaluated. Finally, its inhibitory effects on the nuclear factor-kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signalling pathways were observed in RAW 264.7 cells. In our results, seven active compounds were identified in F. rhynchophylla, and six were associated with seven genes associated with inflammatory dermatosis and exhibited a strong binding affinity (
ISSN:1422-0067
DOI:10.3390/ijms24076091