Effect of Melatonin on the Content of [CD3.sup.low] and [CD3.sup.hi] T Cells in the Thymus of Mice with Functional Pinealectomy

Continuous lighting for 14 days (functional pinealectomy model) leads to a decrease in the relative number of [CD3.sup.low] and [CD3.sup.hi] T lymphocytes and the [CD3.sup.low]/[CD3.sup.hi] ratio in the thymus of C57BL/6 mice. Intragastric administration of melatonin in physiological doses (1 mg/kg...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2023-04, Vol.174 (6), p.754
Main Authors: Michurina, S.V, Miroshnichenko, S.M, Ishchenko, I.Yu, Serykh, A.E, Rachkovskaya, L.N
Format: Article
Language:English
Subjects:
Analysis
Melatonin
Mice
Physiological aspects
T cells
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Summary:Continuous lighting for 14 days (functional pinealectomy model) leads to a decrease in the relative number of [CD3.sup.low] and [CD3.sup.hi] T lymphocytes and the [CD3.sup.low]/[CD3.sup.hi] ratio in the thymus of C57BL/6 mice. Intragastric administration of melatonin in physiological doses (1 mg/kg body weight, 14 days) against the background of functional pinealectomy restores the percentage of [CD3.sup.low] and [CD3.sup.hi] thymocytes and [CD3.sup.low]/[CD3.sup.hi] ratio to the control values. Hence, prolonged continuous illumination inhibits the differentiation and maturation of young thymocytes into mature forms, while melatonin treatment helps to compensate the effects of functional pinealectomy triggering cell proliferation in the thymus from the earliest stages of proliferation and differentiation of T cells. Thus, melatonin has immunotropic properties and can be used for correction of the consequences of functional pinealectomy. Key Words: functional pinealectomy; continuous lighting; melatonin; CDSow thymocytes; [CD3.sup.hi] thymocytes
ISSN:0007-4888
DOI:10.1007/s10517-023-05786-2