The Role of Albumin in the Diagnosis of Neonatal Sepsis Over the Last 11 Years: A Retrospective Study

• Published in: Journal of inflammation research 2023-07, Vol.16, p.2855
• Main Authors: Shi, Jipeng, Lu, Zhen-Qi, Lin, Qing-Mei, Zeng, Wang, Gu, Ping-Jiao, Yu, Qing, Long, Jing, Huang, Da-Gui, Dai, Yi-Heng
• Format: Article
• Language: English
• Subjects: Albumin; Analysis; Blood; C-reactive protein; Children; Health aspects; Infants (Newborn); Medical examination; Neonatology
• ISSN: 1178-7031; 1178-7031
• DOI: 10.2147/JIR.S4l4611

Background: There are many difficulties and uncertainties in the early diagnosis of neonatal sepsis. The aim of this study was to determine whether albumin (ALB) is useful for the early diagnosis of neonatal sepsis using ALB, C-reactive protein (CRP) and procalcitonin (PCT) together. Methods: ALB, CRP, PCT and white blood cell (WBC) data from 732 patients with neonatal sepsis and 1317 neonatal infection patients hospitalized in Foshan Maternal and Child Health Hospital from 2011 to 2022 were collected. Receiver operating characteristic (ROC) and logistic regression analyses were performed to assess the diagnostic value of ALB, CRP, PCT and the WBC count for neonatal sepsis. The roles of ALB, CRP, PCT and the WBC count in the diagnosis of neonatal sepsis were analysed by using subject working characteristics (ROC) and areas under the curve (AUCs), and the variables were combined to determine which combination had the best diagnostic efficacy. Results: In the sepsis group, the ALB, CRP, and PCT levels and the WBC count were significantly higher than those in the infection group (P