Bioprospecting a Film-Forming System Loaded with IEugenia uniflora/I L. and ITropaeolum majus/I L. Leaf Extracts for Topical Application in Treating Skin Lesions

• Published in: Pharmaceuticals (Basel, Switzerland) Switzerland), 2023-07, Vol.16 (8)
• Main Authors: Dalmagro, Mariana, Pinc, Mariana Moraes, Donadel, Guilherme, Tominc, Getulio Capello, Jacomassi, Ezilda, Lourenço, Emerson Luiz Botelho, Gasparotto Junior, Arquimedes, Boscarato, André Giarola, Belettini, Salviano Tramontin, Alberton, Odair, Prochnau, Inara Staub, Bariccatti, Reinaldo Aparecido, Almeida, Rafael Menck de, Rossi de Aguiar, Kelen Menezes Flores, Hoscheid, Jaqueline
• Format: Article
• Language: English
• Subjects: Care and treatment; Chemical properties; Dermatologic agents; Dermatology; Formulae, receipts, prescriptions; Health aspects; Materia medica, Vegetable; Myrtaceae; Nasturtiums; Pharmaceutical research; Plant extracts; Skin lesions
• ISSN: 1424-8247; 1424-8247
• DOI: 10.3390/ph16081068

Natural products can be used as complements or as alternatives to synthetic drugs. Eugenia uniflora and Tropaeolum majus are natives of Brazil and have antimicrobial, anti-inflammatory, and antioxidant activities. This study aimed to develop a film-forming system (FFS) loaded with plant extracts with the potential for treating microbial infections. E. uniflora and T. majus leaf extracts were prepared and characterized, and the individual and combined antioxidant and antimicrobial activities were evaluated. The FFS was developed with different concentrations of polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA) and analyzed for physicochemical characteristics. The combination of extracts showed a superior antioxidant effect compared to the individual extracts, justifying the use of the blend. FFS prepared with 4.5% PVA, 4.5% PVP, 7.81% E. uniflora extract, and 3.90% T. majus extract was adhesive, lacked scale formation, presented good malleability, and had a suitable pH for topical application. In addition, the viscosity at rest was satisfactory for maintaining stability; water solubility was adequate; skin permeation was low; and the antimicrobial effect was superior to that of the individual extracts. Therefore, the developed FFS is promising for the differentiated treatment of skin lesions through topical application.