Detection of Biochemically Recurrent Prostate Cancer with [[sup.18]F]DCFPyL PET/CT: An Updated Systematic Review and Meta-Analysis with a Focus on Correlations with Serum Prostate-Specific Antigen Parameters

[[sup.18]F]DCFPyL is increasingly used for prostate-specific membrane antigen (PSMA) mediated imaging of men with biochemically recurrent prostate cancer (BRPCa). In this meta-analysis, which is updated with the addition of multiple new studies, including the definitive phase III CONDOR trial, we di...

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Bibliographic Details
Published in:Tomography (Ann Arbor) 2023-08, Vol.9 (4)
Main Authors: Sadaghiani, Mohammad S, Sheikhbahaei, Sara, Al-Zaghal, Abdullah, Solnes, Lilja B, Pomper, Ma, Oldan, Jorge D, Ulaner, Gary A, Gorin, Michael A, Rowe, Steven P
Format: Article
Language:English
Subjects:
Antigens
Care and treatment
Diseases
Metastasis
PET imaging
Prostate cancer
Radiotherapy
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Summary:[[sup.18]F]DCFPyL is increasingly used for prostate-specific membrane antigen (PSMA) mediated imaging of men with biochemically recurrent prostate cancer (BRPCa). In this meta-analysis, which is updated with the addition of multiple new studies, including the definitive phase III CONDOR trial, we discuss the detection efficiency of [[sup.18]F]DCFPyL in BRPCa patients. PubMed was searched on 29 September 2022. Studies evaluating the diagnostic performance of [[sup.18]F]DCFPyL among patients with BRPCa were included. The overall pooled detection rate with a 95% confidence interval (95% CI) was calculated among all included studies and stratified among patients with PSA ≥ 2 vs.
ISSN:2379-1381
DOI:10.3390/tomography9040120