IScutellaria baicalensis/I Attenuated Neurological Impairment by Regulating Programmed Cell Death Pathway in Ischemic Stroke Mice

Stroke is a major global health problem that causes significant mortality and long-term disability. Post-stroke neurological impairment is a complication that is often underestimated with the risk of persistent neurological deficits. Although traditional Chinese medicines have a long history of bein...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Switzerland), 2023-08, Vol.12 (17)
Main Authors: Seo, Ho-won, Ha, Tae-Young, Ko, Geon, Jang, Aram, Choi, Ji-Woong, Lee, Dong-hun, Chang, Keun-A
Format: Article
Language:English
Subjects:
Apoptosis
Biochemistry
Brain
Care and treatment
Health aspects
Injuries
Investigations
Ischemia
Medical research
Medicinal plants
Medicine, Experimental
Scullcap
Stroke (Disease)
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Summary:Stroke is a major global health problem that causes significant mortality and long-term disability. Post-stroke neurological impairment is a complication that is often underestimated with the risk of persistent neurological deficits. Although traditional Chinese medicines have a long history of being used for stroke, their scientific efficacy remains unclear. Scutellaria baicalensis, an herbal component known for its anti-inflammatory and antioxidant properties, has traditionally been used to treat brain disorders. This study investigated the therapeutic effects of the Scutellaria baicalensis extraction (SB) during the acute stage of ischemic stroke using photothrombotic (PTB)-induced and transient middle cerebral artery occlusion (tMCAO) model mice. We found that SB mitigated ischemic brain injury, as evidenced by a significant reduction in the modified neurological severity score in the acute stage of PTB and both the acute and chronic stages of tMCAO. Furthermore, we elucidated the regulatory role of SB in the necroptosis and pyroptosis pathways during the acute stage of stroke, underscoring its protective effects. Behavioral assessments demonstrated the effectiveness of SB in ameliorating motor dysfunction and cognitive impairment compared to the group receiving the vehicle. Our findings highlight the potential of SB as a promising therapeutic candidate for stroke. SB was found to help modulate the programmed cell death pathways, promote neuroprotection, and facilitate functional recovery.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells12172133