Effects of CBD as a chronic stress mitigating agent In-vivo

This study evaluates the effects of Cannabidiol (CBD) on the physiology of stressed and non-stressed Nile tilapia, reared in a recirculating aquaculture system. Tilapia were fed with and without CBD (0.001% of feed weight) and with and without hydrocortisone stress hormone (0.01% of body weight) eve...

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Bibliographic Details
Published in:PloS one 2023-09, Vol.18 (9), p.e0290835
Main Authors: Mortuza, Asif, Fahim, Nahian, Ahmed, Malaika, Mustafa, Ahmed
Format: Article
Language:English
Subjects:
Agricultural industry
Aquaculture industry
Blood sugar
Body weight
Comparative analysis
Corticosteroids
Costs (Law)
Fishes
Health aspects
Lysozyme
Management
Mediation
Physiological aspects
Stress (Psychology)
Tilapia
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Summary:This study evaluates the effects of Cannabidiol (CBD) on the physiology of stressed and non-stressed Nile tilapia, reared in a recirculating aquaculture system. Tilapia were fed with and without CBD (0.001% of feed weight) and with and without hydrocortisone stress hormone (0.01% of body weight) every day for four weeks. This experiment compared the plasma cortisol, blood glucose and protein levels, liver and spleen somatic indices (HSI and SSI, respectively), and lysozyme activity of the fish. Stress group (S) had a significantly higher value than the control group (C) in two of the parameters, glucose and lysozyme activity, this is an indication of stress. CBD had a stress reducing effect under stressed conditions in lysozyme activity. Although not significant, the stress reducing effect of CBD on stress biomarkers such as glucose and HSI also seemed promising. Further investigation into the matter may not just be useful in stress mediation in aquatic organisms but may also have implications in human medicine as well.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0290835