Evaluation of the Cholesterol-Lowering Mechanism of IEnterococcus faecium/I Strain 132 and ILactobacillus paracasei/I Strain 201 in Hypercholesterolemia Rats

Hypercholesterolemia can cause many diseases, but it can effectively regulated by Lactobacillus. This study aimed to evaluate the cholesterol-lowering mechanism of Enterococcus faecium strain 132 and Lactobacillusparacasei strain 201. These results showed that both the strains decreased serum total...

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Published in:Nutrients 2021-06, Vol.13 (6)
Main Authors: Yang, Lingshuang, Xie, Xinqiang, Li, Ying, Wu, Lei, Fan, Congcong, Liang, Tingting, Xi, Yu, Yang, Shuanghong, Li, Haixin, Zhang, Jumei, Ding, Yu, Xue, Liang, Chen, Moutong, Wang, Juan, Wu, Qingping
Format: Article
Language:English
Subjects:
Acetic acid
Anticholesteremic agents
Bile acids
Cholesterol
Hypercholesterolemia
Inflammation
Liver
Low density lipoproteins
Microbiota (Symbiotic organisms)
Triglycerides
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Summary:Hypercholesterolemia can cause many diseases, but it can effectively regulated by Lactobacillus. This study aimed to evaluate the cholesterol-lowering mechanism of Enterococcus faecium strain 132 and Lactobacillusparacasei strain 201. These results showed that both the strains decreased serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), liver TC and TG and increased fecal TC, TG and total bile acid (TBA) levels. Additionally, both strains also reduced glutamic-pyruvic transaminase (ALT), glutamic oxaloacetic transaminase (AST) and levels of tissue inflammation levels to improve the lipid profile, and they reduced fat accumulation partially by alleviating inflammatory responses. Furthermore, both strains regulated the expression of the CYP8B1, CYP7A1, SREBP-1, SCD1 and LDL-R gene to promote cholesterol metabolism and reduce TG accumulation. Interventions with both strains also altered the gut microbiota, and decreasing the abundance of Veillonellaceae, Erysipelotrichaceae and Prevotella. Furthermore, fecal acetic acid and propionic acid were increased by this intervention. Overall, the results suggested that E. faecium strain 132 and L. paracasei strain 201 can alleviate hypercholesterolemia in rats and might be applied as a new type of hypercholesterolemia agent in functional foods.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu13061982