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Synthesis and Antimicrobial Activity of 2,5-Diaryl-8,8-Dimethyl-3,6,7,8-Tetrahydro-2H-Pyrido[4,3,2-de]Cinnolin-3-Ones
The computer program Prediction of Activity Spectra for Substances (PASS), which allows a prediction of the spectrum of biological activity of chemical compounds based on an analysis of their structure(activity relationships, was used to predict the biological activity of new promising derivatives o...
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| Published in: | Pharmaceutical chemistry journal 2023-08, Vol.57 (5), p.632-636 |
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| container_end_page | 636 |
| container_issue | 5 |
| container_start_page | 632 |
| container_title | Pharmaceutical chemistry journal |
| container_volume | 57 |
| creator | Shurov, S. N. Lystsova, E. A. Zykova, S. S. Namyatova, K. V. Chernykh, T. F. Bogdanova, O. Yu Tsvetkova, I. A. |
| description | The computer program Prediction of Activity Spectra for Substances (PASS), which allows a prediction of the spectrum of biological activity of chemical compounds based on an analysis of their structure(activity relationships, was used to predict the biological activity of new promising derivatives of 2,5-diaryl-8,8-dimethyl-3,6,7,8-tetrahydro-2
H
-pyrido[4,3,2-
de
]cinnolin-3-ones. Screening of the compounds found that 2,5-diaryl-8,8-dimethyl-3,6,7,8-tetrahydro-2
H
-pyrido[4,3,2-
de
]cinnolin-3-ones could exhibit antibacterial and antifungal activity. The antimicrobial activity of the synthesized compounds was studied against Gram-positive and Gram-negative bacteria and yeast and mold fungi. The compounds were shown to have an inhibitory effect on some types of Gram-positive bacteria and fungi. 8,8-Dimethyl-2-
p
-tolyl-5-
p
-chlorophenyl-3,7,8,9-tetrahydro-2
H
-pyrido[4,3,2-
de
]cinnolin-3-one had a minimum inhibitory concentration of 48 μg/mL for Gram-positive bacteria and possessed the most pronounced antimicrobial activity of the tested compounds. |
| doi_str_mv | 10.1007/s11094-023-02930-0 |
| format | article |
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H
-pyrido[4,3,2-
de
]cinnolin-3-ones. Screening of the compounds found that 2,5-diaryl-8,8-dimethyl-3,6,7,8-tetrahydro-2
H
-pyrido[4,3,2-
de
]cinnolin-3-ones could exhibit antibacterial and antifungal activity. The antimicrobial activity of the synthesized compounds was studied against Gram-positive and Gram-negative bacteria and yeast and mold fungi. The compounds were shown to have an inhibitory effect on some types of Gram-positive bacteria and fungi. 8,8-Dimethyl-2-
p
-tolyl-5-
p
-chlorophenyl-3,7,8,9-tetrahydro-2
H
-pyrido[4,3,2-
de
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H
-pyrido[4,3,2-
de
]cinnolin-3-ones. Screening of the compounds found that 2,5-diaryl-8,8-dimethyl-3,6,7,8-tetrahydro-2
H
-pyrido[4,3,2-
de
]cinnolin-3-ones could exhibit antibacterial and antifungal activity. The antimicrobial activity of the synthesized compounds was studied against Gram-positive and Gram-negative bacteria and yeast and mold fungi. The compounds were shown to have an inhibitory effect on some types of Gram-positive bacteria and fungi. 8,8-Dimethyl-2-
p
-tolyl-5-
p
-chlorophenyl-3,7,8,9-tetrahydro-2
H
-pyrido[4,3,2-
de
]cinnolin-3-one had a minimum inhibitory concentration of 48 μg/mL for Gram-positive bacteria and possessed the most pronounced antimicrobial activity of the tested compounds.</description><subject>Antifungal agents</subject><subject>Bacteria</subject><subject>Medicine</subject><subject>Molds (Fungi)</subject><subject>Organic Chemistry</subject><subject>Pharmacology/Toxicology</subject><subject>Pharmacy</subject><subject>Search for New Drugs</subject><issn>0091-150X</issn><issn>1573-9031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kV9LwzAUxYMoOKdfwKeCr43e5DZN-zjmnwmCggqCSMia1EW6VJJO6Lc3Ol8EkRCSXM4v3HsOIccMThmAPIuMQV1Q4Jh2jUBhh0yYkEhrQLZLJgA1o0zA0z45iPENIGHIJ2RzP_phZaOLmfYmm_nBrV0T-qXTXTZrBvfhhjHr24zngp47HcaOVnmVrms7rNID8zKXqfBgh6BXowk95Qt6NwZn-ucix5xTY1_mzvu-c54ivfU2HpK9VnfRHv2cU_J4efEwX9Cb26vr-eyGNgj1QBshSr7UlkmLrWQIQkouecErqBsUvCqMhoIxUwmt-bIU2i6NNYAN1BVUAqfkZPvvq-6scr7tU5PN2sVGzWRZIkhRYlKd_qFKy9jkRe9t61L9F8C3QDIqxmBb9R7cOnmjGKivPNQ2D5XyUN95KEgQbqGYxP7VBvXWb4JP4_9HfQKHCYkz</recordid><startdate>20230801</startdate><enddate>20230801</enddate><creator>Shurov, S. N.</creator><creator>Lystsova, E. A.</creator><creator>Zykova, S. S.</creator><creator>Namyatova, K. V.</creator><creator>Chernykh, T. F.</creator><creator>Bogdanova, O. Yu</creator><creator>Tsvetkova, I. A.</creator><general>Springer US</general><general>Springer</general><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20230801</creationdate><title>Synthesis and Antimicrobial Activity of 2,5-Diaryl-8,8-Dimethyl-3,6,7,8-Tetrahydro-2H-Pyrido[4,3,2-de]Cinnolin-3-Ones</title><author>Shurov, S. N. ; Lystsova, E. A. ; Zykova, S. S. ; Namyatova, K. V. ; Chernykh, T. F. ; Bogdanova, O. Yu ; Tsvetkova, I. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-c5562bae17e3f713057727242809c35284da0411d85aa2b65aebded03c0980853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antifungal agents</topic><topic>Bacteria</topic><topic>Medicine</topic><topic>Molds (Fungi)</topic><topic>Organic Chemistry</topic><topic>Pharmacology/Toxicology</topic><topic>Pharmacy</topic><topic>Search for New Drugs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shurov, S. N.</creatorcontrib><creatorcontrib>Lystsova, E. A.</creatorcontrib><creatorcontrib>Zykova, S. S.</creatorcontrib><creatorcontrib>Namyatova, K. V.</creatorcontrib><creatorcontrib>Chernykh, T. F.</creatorcontrib><creatorcontrib>Bogdanova, O. Yu</creatorcontrib><creatorcontrib>Tsvetkova, I. A.</creatorcontrib><collection>CrossRef</collection><jtitle>Pharmaceutical chemistry journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shurov, S. N.</au><au>Lystsova, E. A.</au><au>Zykova, S. S.</au><au>Namyatova, K. V.</au><au>Chernykh, T. F.</au><au>Bogdanova, O. Yu</au><au>Tsvetkova, I. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and Antimicrobial Activity of 2,5-Diaryl-8,8-Dimethyl-3,6,7,8-Tetrahydro-2H-Pyrido[4,3,2-de]Cinnolin-3-Ones</atitle><jtitle>Pharmaceutical chemistry journal</jtitle><stitle>Pharm Chem J</stitle><date>2023-08-01</date><risdate>2023</risdate><volume>57</volume><issue>5</issue><spage>632</spage><epage>636</epage><pages>632-636</pages><issn>0091-150X</issn><eissn>1573-9031</eissn><abstract>The computer program Prediction of Activity Spectra for Substances (PASS), which allows a prediction of the spectrum of biological activity of chemical compounds based on an analysis of their structure(activity relationships, was used to predict the biological activity of new promising derivatives of 2,5-diaryl-8,8-dimethyl-3,6,7,8-tetrahydro-2
H
-pyrido[4,3,2-
de
]cinnolin-3-ones. Screening of the compounds found that 2,5-diaryl-8,8-dimethyl-3,6,7,8-tetrahydro-2
H
-pyrido[4,3,2-
de
]cinnolin-3-ones could exhibit antibacterial and antifungal activity. The antimicrobial activity of the synthesized compounds was studied against Gram-positive and Gram-negative bacteria and yeast and mold fungi. The compounds were shown to have an inhibitory effect on some types of Gram-positive bacteria and fungi. 8,8-Dimethyl-2-
p
-tolyl-5-
p
-chlorophenyl-3,7,8,9-tetrahydro-2
H
-pyrido[4,3,2-
de
]cinnolin-3-one had a minimum inhibitory concentration of 48 μg/mL for Gram-positive bacteria and possessed the most pronounced antimicrobial activity of the tested compounds.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11094-023-02930-0</doi><tpages>5</tpages></addata></record> |
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| ispartof | Pharmaceutical chemistry journal, 2023-08, Vol.57 (5), p.632-636 |
| issn | 0091-150X 1573-9031 |
| language | eng |
| recordid | cdi_gale_infotracmisc_A766307563 |
| source | Springer Nature |
| subjects | Antifungal agents Bacteria Medicine Molds (Fungi) Organic Chemistry Pharmacology/Toxicology Pharmacy Search for New Drugs |
| title | Synthesis and Antimicrobial Activity of 2,5-Diaryl-8,8-Dimethyl-3,6,7,8-Tetrahydro-2H-Pyrido[4,3,2-de]Cinnolin-3-Ones |
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