Serum CCL20: A novel potential marker of cardiovascular risk in alopecia areata patients

Background Alopecia areata (AA) is a prevalent autoimmune skin disease that may be associated with systemic disorders. The connection between cardiovascular risks and AA is not widely investigated. Chemokine (C-C motif) ligand 20 (CCL20) has been found to be related to cardiovascular comorbidities....

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Bibliographic Details
Published in:Journal of the Egyptian Women’s Dermatologic Society 2023-09, Vol.20 (3), p.173-178
Main Authors: Hamed, Ahmed, Abdelmaksoud, Amal, Elfallah, Asmaa, Sweed, Enas, Ibrahim, Samah
Format: Article
Language:English
Subjects:
Alopecia
alopecia areata
atherosclerosis
B cells
Baldness
C-reactive protein
Cardiovascular diseases
carotid intima media thickness
ccl20
Comorbidity
Medical research
Medicine, Experimental
Risk factors
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Summary:Background Alopecia areata (AA) is a prevalent autoimmune skin disease that may be associated with systemic disorders. The connection between cardiovascular risks and AA is not widely investigated. Chemokine (C-C motif) ligand 20 (CCL20) has been found to be related to cardiovascular comorbidities. Objective To investigate the role of CCL20 in AA patients and its relation to cardiovascular comorbidity. Patients and methods This study enrolled 80 AA patients and 40 age and sex-matched control subjects. Serums CCL20, high sensitive C- reactive protein (Hs-CRP), lipid profile in addition to carotid intima-media thickness (CIMT) were investigated in all subjects. Results AA patients expressed significantly higher serum CCL20 levels than healthy controls (29.6±20.4 vs. 10.3±6.7, P
ISSN:1687-1537
2090-2565
DOI:10.4103/jewd.jewd_27_23