Relationship between CONUT score and mortality in patients with pulmonary arterial hypertension/Pulmoner arteriyel hipertansiyonlu hastalarda nutrisyonel durum kontrolu skorunun mortalite ile iliskisi

Purpose: Data about the association of malnutrition with prognosis in pulmonary arterial hypertension (PAH) is limited. This study aims to evaluate the relationship of Controlling Nutritional Status (CONUT) score with long- term mortality in PAH. Materials and methods: All consecutive patients newly...

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Published in:Pamukkale Medical Journal 2023-10, Vol.16 (4), p.548
Main Authors: Sungur, Mustafa Azmi, Sungur, Aylin, Can, Fatma, Zencirci, Aycan Esen, Gungor, Baris, Yildirimturk, Ozlem
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Albumin
Analysis
Mortality
Patient outcomes
Prognosis
Pulmonary hypertension
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Sungur, Aylin
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Gungor, Baris
Yildirimturk, Ozlem
description Purpose: Data about the association of malnutrition with prognosis in pulmonary arterial hypertension (PAH) is limited. This study aims to evaluate the relationship of Controlling Nutritional Status (CONUT) score with long- term mortality in PAH. Materials and methods: All consecutive patients newly diagnosed with PAH between 2013 and 2020 were evaluated. CONUT score at diagnosis was calculated through total lymphocyte, albumin and total cholesterol levels. Primary outcome was long-term all-cause mortality. Patients were followed up for 62 (31.3-91.5) months. Results: 92 patients (mean age=43.9 [+ or -] 15.7 years, 65.2% women) were included. 37% of the patients had any degree of malnutrition according to CONUT score ([greater than or equal to] 2). Patients without malnutrition were significantly more in the low-risk categories of risk stratification tools (44.8% vs 17.6% according to ESC/ERS guideline, p=0.03; 70.7% vs 35.3% and 70.7% vs 32.4% according to REVEAL 2.0 and REVEAL Lite 2, p
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This study aims to evaluate the relationship of Controlling Nutritional Status (CONUT) score with long- term mortality in PAH. Materials and methods: All consecutive patients newly diagnosed with PAH between 2013 and 2020 were evaluated. CONUT score at diagnosis was calculated through total lymphocyte, albumin and total cholesterol levels. Primary outcome was long-term all-cause mortality. Patients were followed up for 62 (31.3-91.5) months. Results: 92 patients (mean age=43.9 [+ or -] 15.7 years, 65.2% women) were included. 37% of the patients had any degree of malnutrition according to CONUT score ([greater than or equal to] 2). Patients without malnutrition were significantly more in the low-risk categories of risk stratification tools (44.8% vs 17.6% according to ESC/ERS guideline, p=0.03; 70.7% vs 35.3% and 70.7% vs 32.4% according to REVEAL 2.0 and REVEAL Lite 2, p&lt;0.01 for both). In multivariate analysis, CONUT score predicted all-cause mortality (HR:1.51, 95% CI:1.01-1.52, p=0.03) independently after adjustment with ESC/ERS guideline risk score. Conclusion: CONUT score is independently associated with worse outcome in PAH patients and may indicate severe disease in this patient group. Keywords: Pulmonary arterial hypertension, malnutrition, controlling nutritional status score, mortality. Sungur MA, Sungur A, Can F, Esen Zencirci A, Gungor B, Yildirimturk O. Relationship between CONUT score and mortality in patients with pulmonary arterial hypertension. Pam Med J 2023;16:548-556. Amac: Bircok kronik hastalikta olumsuz sonuclarla iliskili oldugu gosterilen malnutrisyonun, pulmoner arteriyel hipertansiyonda (PAH) prognoz ile iliskisi net degildir. Bu calismada, PAH hastaliginda Nutrisyonel Durum Kontrolu (CONUT) skoru ile uzun donem mortalite arasindaki iliskiyi degerlendirmeyi amacladik. Gerec ve yontem: 2013 ve 2020 tarihleri arasinda PAH tanisi alan tum ardisik hastalar retrospektif olarak incelendi. Tani anindaki CONUT skoru; toplam lenfosit sayisi, albumin ve total kolesterol duzeyleri ile hesaplandi. Birincil sonlanim uzun donem tum nedenlere bagli mortalite olarak belirlendi. Hastalar 62 (31,3-91,5) ay takip edildi. Bulgular: Calismaya 92 hasta dahil edildi. Ortalama yasi 43,9 [+ or -] 15,7 olan hasta grubunun %65,2'si kadindi. Hastalarin %37'sinde CONUT skoruna gore herhangi bir derecede malnutrisyon mevcuttu (CONUT skoru [greater than or equal to] 2). Malnutrisyon tespit edilmeyen hastalar, risk degerlendirme skorlarina gore dusuk risk kategorisinde anlamli olarak daha fazla yer almaktaydi (ESC/ERS kilavuzu risk skorlama sistemine gore %44,8'e karsi %17,6, p=0,03; REVEAL 2.0 risk siniflamasina gore %70,7'ye karsi %35,3, p&lt;0,01; REVEAL Lite 2 risk siniflamasina gore %70,7'ye karsi %32,4, p&lt;0,01). Cok degiskenli analizde, ESC/ERS kilavuzu risk skoru ile duzeltme yapildiktan sonra, CONUT skoru (HR:1,51, 95% CI:1,01-1,52, p=0,03) uzun donem tum nedenlere bagli mortaliteyi bagimsiz olarak ongordurmekteydi. Sonuc: CONUT skoru, PAH'li hastalarda kotu prognoz ile iliskilidir ve bu hasta grubunda hastaligin siddetini gosterebilir. Anahtar kelimeler: Pulmoner arteriyel hipertansiyon, malnutrisyon, nutrisyonel durum kontrolu skoru, mortalite.</description><identifier>ISSN: 1309-9833</identifier><identifier>DOI: 10.31362/patd.1324430</identifier><language>eng</language><publisher>Pamukkale University</publisher><subject>Albumin ; Analysis ; Mortality ; Patient outcomes ; Prognosis ; Pulmonary hypertension</subject><ispartof>Pamukkale Medical Journal, 2023-10, Vol.16 (4), p.548</ispartof><rights>COPYRIGHT 2023 Pamukkale University</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Sungur, Mustafa Azmi</creatorcontrib><creatorcontrib>Sungur, Aylin</creatorcontrib><creatorcontrib>Can, Fatma</creatorcontrib><creatorcontrib>Zencirci, Aycan Esen</creatorcontrib><creatorcontrib>Gungor, Baris</creatorcontrib><creatorcontrib>Yildirimturk, Ozlem</creatorcontrib><title>Relationship between CONUT score and mortality in patients with pulmonary arterial hypertension/Pulmoner arteriyel hipertansiyonlu hastalarda nutrisyonel durum kontrolu skorunun mortalite ile iliskisi</title><title>Pamukkale Medical Journal</title><description>Purpose: Data about the association of malnutrition with prognosis in pulmonary arterial hypertension (PAH) is limited. This study aims to evaluate the relationship of Controlling Nutritional Status (CONUT) score with long- term mortality in PAH. Materials and methods: All consecutive patients newly diagnosed with PAH between 2013 and 2020 were evaluated. CONUT score at diagnosis was calculated through total lymphocyte, albumin and total cholesterol levels. Primary outcome was long-term all-cause mortality. Patients were followed up for 62 (31.3-91.5) months. Results: 92 patients (mean age=43.9 [+ or -] 15.7 years, 65.2% women) were included. 37% of the patients had any degree of malnutrition according to CONUT score ([greater than or equal to] 2). Patients without malnutrition were significantly more in the low-risk categories of risk stratification tools (44.8% vs 17.6% according to ESC/ERS guideline, p=0.03; 70.7% vs 35.3% and 70.7% vs 32.4% according to REVEAL 2.0 and REVEAL Lite 2, p&lt;0.01 for both). In multivariate analysis, CONUT score predicted all-cause mortality (HR:1.51, 95% CI:1.01-1.52, p=0.03) independently after adjustment with ESC/ERS guideline risk score. Conclusion: CONUT score is independently associated with worse outcome in PAH patients and may indicate severe disease in this patient group. Keywords: Pulmonary arterial hypertension, malnutrition, controlling nutritional status score, mortality. Sungur MA, Sungur A, Can F, Esen Zencirci A, Gungor B, Yildirimturk O. Relationship between CONUT score and mortality in patients with pulmonary arterial hypertension. Pam Med J 2023;16:548-556. Amac: Bircok kronik hastalikta olumsuz sonuclarla iliskili oldugu gosterilen malnutrisyonun, pulmoner arteriyel hipertansiyonda (PAH) prognoz ile iliskisi net degildir. Bu calismada, PAH hastaliginda Nutrisyonel Durum Kontrolu (CONUT) skoru ile uzun donem mortalite arasindaki iliskiyi degerlendirmeyi amacladik. Gerec ve yontem: 2013 ve 2020 tarihleri arasinda PAH tanisi alan tum ardisik hastalar retrospektif olarak incelendi. Tani anindaki CONUT skoru; toplam lenfosit sayisi, albumin ve total kolesterol duzeyleri ile hesaplandi. Birincil sonlanim uzun donem tum nedenlere bagli mortalite olarak belirlendi. Hastalar 62 (31,3-91,5) ay takip edildi. Bulgular: Calismaya 92 hasta dahil edildi. Ortalama yasi 43,9 [+ or -] 15,7 olan hasta grubunun %65,2'si kadindi. Hastalarin %37'sinde CONUT skoruna gore herhangi bir derecede malnutrisyon mevcuttu (CONUT skoru [greater than or equal to] 2). Malnutrisyon tespit edilmeyen hastalar, risk degerlendirme skorlarina gore dusuk risk kategorisinde anlamli olarak daha fazla yer almaktaydi (ESC/ERS kilavuzu risk skorlama sistemine gore %44,8'e karsi %17,6, p=0,03; REVEAL 2.0 risk siniflamasina gore %70,7'ye karsi %35,3, p&lt;0,01; REVEAL Lite 2 risk siniflamasina gore %70,7'ye karsi %32,4, p&lt;0,01). Cok degiskenli analizde, ESC/ERS kilavuzu risk skoru ile duzeltme yapildiktan sonra, CONUT skoru (HR:1,51, 95% CI:1,01-1,52, p=0,03) uzun donem tum nedenlere bagli mortaliteyi bagimsiz olarak ongordurmekteydi. Sonuc: CONUT skoru, PAH'li hastalarda kotu prognoz ile iliskilidir ve bu hasta grubunda hastaligin siddetini gosterebilir. Anahtar kelimeler: Pulmoner arteriyel hipertansiyon, malnutrisyon, nutrisyonel durum kontrolu skoru, mortalite.</description><subject>Albumin</subject><subject>Analysis</subject><subject>Mortality</subject><subject>Patient outcomes</subject><subject>Prognosis</subject><subject>Pulmonary hypertension</subject><issn>1309-9833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNptj01rwzAMhnPYYKXbcXfDzmntOHHiYyn7grKO0Z2LE8uN18QutkPJP9zPmruVscMQQkLPqxcpSW4JnlFCWTY_iCBnhGZ5TvFFMiEU85RXlF4lN95_YIwznhdFxifJ5xt0ImhrfKsPqIZwBDBouX553yDfWAdIGIl664LodBiRNiiaazDBo6MOLToMXW-NcCMSLoDTokPteIDYGx9t56_fHNwZjxC5PnER-WhNN6BW-OgunBTIDMFpH8dRJgc39GhvTXA2qvzeusEM5vcYQLo7pfZ77fV1cqlE5-HmXKfJ5uF-s3xKV-vH5-Vile5YSVPSlIrQghGmcqgzzDBmkmW0ASUhr2oRZ3VV1aA4qUual0QUtVSMc94wVeV0mtz92O5EB1ttlA1ONL32zXZRsqrElGQ0qmb_qGJI6HUTv1Px9L8LX3Vlj6k</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Sungur, Mustafa Azmi</creator><creator>Sungur, Aylin</creator><creator>Can, Fatma</creator><creator>Zencirci, Aycan Esen</creator><creator>Gungor, Baris</creator><creator>Yildirimturk, Ozlem</creator><general>Pamukkale University</general><scope/></search><sort><creationdate>20231001</creationdate><title>Relationship between CONUT score and mortality in patients with pulmonary arterial hypertension/Pulmoner arteriyel hipertansiyonlu hastalarda nutrisyonel durum kontrolu skorunun mortalite ile iliskisi</title><author>Sungur, Mustafa Azmi ; Sungur, Aylin ; Can, Fatma ; Zencirci, Aycan Esen ; Gungor, Baris ; Yildirimturk, Ozlem</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g673-1c7f135616f4eb206006d623cefde48bab20b88bef91b73471a5bdf6999c6f843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Albumin</topic><topic>Analysis</topic><topic>Mortality</topic><topic>Patient outcomes</topic><topic>Prognosis</topic><topic>Pulmonary hypertension</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sungur, Mustafa Azmi</creatorcontrib><creatorcontrib>Sungur, Aylin</creatorcontrib><creatorcontrib>Can, Fatma</creatorcontrib><creatorcontrib>Zencirci, Aycan Esen</creatorcontrib><creatorcontrib>Gungor, Baris</creatorcontrib><creatorcontrib>Yildirimturk, Ozlem</creatorcontrib><jtitle>Pamukkale Medical Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sungur, Mustafa Azmi</au><au>Sungur, Aylin</au><au>Can, Fatma</au><au>Zencirci, Aycan Esen</au><au>Gungor, Baris</au><au>Yildirimturk, Ozlem</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relationship between CONUT score and mortality in patients with pulmonary arterial hypertension/Pulmoner arteriyel hipertansiyonlu hastalarda nutrisyonel durum kontrolu skorunun mortalite ile iliskisi</atitle><jtitle>Pamukkale Medical Journal</jtitle><date>2023-10-01</date><risdate>2023</risdate><volume>16</volume><issue>4</issue><spage>548</spage><pages>548-</pages><issn>1309-9833</issn><abstract>Purpose: Data about the association of malnutrition with prognosis in pulmonary arterial hypertension (PAH) is limited. This study aims to evaluate the relationship of Controlling Nutritional Status (CONUT) score with long- term mortality in PAH. Materials and methods: All consecutive patients newly diagnosed with PAH between 2013 and 2020 were evaluated. CONUT score at diagnosis was calculated through total lymphocyte, albumin and total cholesterol levels. Primary outcome was long-term all-cause mortality. Patients were followed up for 62 (31.3-91.5) months. Results: 92 patients (mean age=43.9 [+ or -] 15.7 years, 65.2% women) were included. 37% of the patients had any degree of malnutrition according to CONUT score ([greater than or equal to] 2). Patients without malnutrition were significantly more in the low-risk categories of risk stratification tools (44.8% vs 17.6% according to ESC/ERS guideline, p=0.03; 70.7% vs 35.3% and 70.7% vs 32.4% according to REVEAL 2.0 and REVEAL Lite 2, p&lt;0.01 for both). In multivariate analysis, CONUT score predicted all-cause mortality (HR:1.51, 95% CI:1.01-1.52, p=0.03) independently after adjustment with ESC/ERS guideline risk score. Conclusion: CONUT score is independently associated with worse outcome in PAH patients and may indicate severe disease in this patient group. Keywords: Pulmonary arterial hypertension, malnutrition, controlling nutritional status score, mortality. Sungur MA, Sungur A, Can F, Esen Zencirci A, Gungor B, Yildirimturk O. Relationship between CONUT score and mortality in patients with pulmonary arterial hypertension. Pam Med J 2023;16:548-556. Amac: Bircok kronik hastalikta olumsuz sonuclarla iliskili oldugu gosterilen malnutrisyonun, pulmoner arteriyel hipertansiyonda (PAH) prognoz ile iliskisi net degildir. Bu calismada, PAH hastaliginda Nutrisyonel Durum Kontrolu (CONUT) skoru ile uzun donem mortalite arasindaki iliskiyi degerlendirmeyi amacladik. Gerec ve yontem: 2013 ve 2020 tarihleri arasinda PAH tanisi alan tum ardisik hastalar retrospektif olarak incelendi. Tani anindaki CONUT skoru; toplam lenfosit sayisi, albumin ve total kolesterol duzeyleri ile hesaplandi. Birincil sonlanim uzun donem tum nedenlere bagli mortalite olarak belirlendi. Hastalar 62 (31,3-91,5) ay takip edildi. Bulgular: Calismaya 92 hasta dahil edildi. Ortalama yasi 43,9 [+ or -] 15,7 olan hasta grubunun %65,2'si kadindi. Hastalarin %37'sinde CONUT skoruna gore herhangi bir derecede malnutrisyon mevcuttu (CONUT skoru [greater than or equal to] 2). Malnutrisyon tespit edilmeyen hastalar, risk degerlendirme skorlarina gore dusuk risk kategorisinde anlamli olarak daha fazla yer almaktaydi (ESC/ERS kilavuzu risk skorlama sistemine gore %44,8'e karsi %17,6, p=0,03; REVEAL 2.0 risk siniflamasina gore %70,7'ye karsi %35,3, p&lt;0,01; REVEAL Lite 2 risk siniflamasina gore %70,7'ye karsi %32,4, p&lt;0,01). Cok degiskenli analizde, ESC/ERS kilavuzu risk skoru ile duzeltme yapildiktan sonra, CONUT skoru (HR:1,51, 95% CI:1,01-1,52, p=0,03) uzun donem tum nedenlere bagli mortaliteyi bagimsiz olarak ongordurmekteydi. Sonuc: CONUT skoru, PAH'li hastalarda kotu prognoz ile iliskilidir ve bu hasta grubunda hastaligin siddetini gosterebilir. Anahtar kelimeler: Pulmoner arteriyel hipertansiyon, malnutrisyon, nutrisyonel durum kontrolu skoru, mortalite.</abstract><pub>Pamukkale University</pub><doi>10.31362/patd.1324430</doi></addata></record>
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subjects Albumin
Analysis
Mortality
Patient outcomes
Prognosis
Pulmonary hypertension
title Relationship between CONUT score and mortality in patients with pulmonary arterial hypertension/Pulmoner arteriyel hipertansiyonlu hastalarda nutrisyonel durum kontrolu skorunun mortalite ile iliskisi
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