Fucoxanthin alters the apelin-13/APJ pathway in certain organs of [gamma] -irradiated mice

Apelin-13 and APJ are implicated in different key physiological processes. This work aims at exploring the radioprotective effect of fucoxanthin (FX) on [gamma]-radiation (RAD)-induced changes in the apelin-13/APJ pathway, which causes damage in the liver, kidney, lung and spleen of mice. Mice were...

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Bibliographic Details
Published in:Journal of radiation research 2021-07, Vol.62 (4)
Main Authors: Bakary, Nermeen M. El, Thabet, Noura Magdy, Fatih, Neama M. El, Abdel-Rafei, Mohamed Khairy, Tawill, Ghada El, Azab, Khaled Shaaban
Format: Article
Language:English
Subjects:
Antioxidants
Interleukins
Liver diseases
Physiological aspects
Radiation
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Summary:Apelin-13 and APJ are implicated in different key physiological processes. This work aims at exploring the radioprotective effect of fucoxanthin (FX) on [gamma]-radiation (RAD)-induced changes in the apelin-13/APJ pathway, which causes damage in the liver, kidney, lung and spleen of mice. Mice were administered FX (10 mg k[g.sup.-1] [day.sup.-1], i.p) and exposed to [gamma]-radiation (2.5 Gy [week.sup.-1]) for four consecutive weeks. The treatment of irradiated mice by FX resulted in a significant amendment in protein expression of the apelin-13/APJ/NF-[kappa]B signalling pathway concurrently with reduced hypoxia (hypoxia-inducible factor-1[alpha]), suppressed oxidative stress marker (malondialdehyde), enhanced antioxidant defence mechanisms (reduced glutathione and glutathione peroxidase), a modulated inflammatory response [interleukin-6 (IL-6), monocyte chemoattractant protein-1, IL-10 and [alpha]-7-nicotinic acetylcholine receptor) and ameliorated angiogenic regulators [matrix metalloproteinase (MMP-2), MMP-9 and tissue inhibitor of metalloproteinase-1), as well as the tissue damage indicator (lactate dehydrogenase) in organ tissues. In addition, there were significant improvement in serum inflammatory markers tumour necrosis factor-[alpha], IL-10, IL-1[beta] and C -reactive protein compared with irradiated mice. The histopathological investigation of the FX + RAD organ tissues support the biochemical fin dings where the improvements in the tissues' architecture were obvious when compared with those of RAD. FX was thus shown to have a noticeable radioprotective action mediated through its regulatory effect on the apelin-13/APJ/NF-[kappa]B signalling pathway attributed to its antioxidant and anti-inflammatory activity that was reflected in different physiological processes. It could be recommended to use FX in cases of radiation exposure to protect normal tissues. Keywords: Fucoxanthin; [gamma]-radiation; MMP-9; Apelin-13/APJ; [alpha]-7nAchR
ISSN:0449-3060
DOI:10.1093/jrr/rraa141