New Weapons to Fight against IStaphylococcus aureus/I Skin Infections

The treatment of Staphylococcus aureus skin and soft tissue infections faces several challenges, such as the increased incidence of antibiotic-resistant strains and the fact that the antibiotics available to treat methicillin-resistant S. aureus present low bioavailability, are not easily metabolize...

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Bibliographic Details
Published in:Antibiotics (Basel) 2023-09, Vol.12 (10)
Main Authors: Cela, Eliana M, Urquiza, Dolores, Gómez, Marisa I, Gonzalez, Cintia D
Format: Article
Language:English
Subjects:
Antibiotics
Bacteria
Drug resistance in microorganisms
Health aspects
Infection
Methicillin
Metronidazole
Penicillin G
Polysaccharides
Skin
Staphylococcus aureus
Staphylococcus aureus infections
Sulbactam
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Summary:The treatment of Staphylococcus aureus skin and soft tissue infections faces several challenges, such as the increased incidence of antibiotic-resistant strains and the fact that the antibiotics available to treat methicillin-resistant S. aureus present low bioavailability, are not easily metabolized, and cause severe secondary effects. Moreover, besides the susceptibility pattern of the S. aureus isolates detected in vitro, during patient treatment, the antibiotics may never encounter the bacteria because S. aureus hides within biofilms or inside eukaryotic cells. In addition, vascular compromise as well as other comorbidities of the patient may impede proper arrival to the skin when the antibiotic is given parenterally. In this manuscript, we revise some of the more promising strategies to improve antibiotic sensitivity, bioavailability, and delivery, including the combination of antibiotics with bactericidal nanomaterials, chemical inhibitors, antisense oligonucleotides, and lytic enzymes, among others. In addition, alternative non-antibiotic-based experimental therapies, including the delivery of antimicrobial peptides, bioactive glass nanoparticles or nanocrystalline cellulose, phototherapies, and hyperthermia, are also reviewed.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics12101477