Fe[sub.3]O[sub.4] Magnetic Nanoparticles Obtained by the Novel Aerosol-Based Technique for Theranostic Applications

This work is aimed at presenting a novel aerosol-based technique for the synthesis of magnetite nanoparticles (Fe[sub.3]O[sub.4] NPs) and to assess the potential medical application of their dispersions after being coated with TEA-oleate. Refinement of the processing conditions led to the formation...

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Published in:Materials 2023-09, Vol.16 (19)
Main Authors: Pawlik, Piotr, Błasiak, Barbara, Pruba, Marcin, Miaskowski, Arkadiusz, Moraczyński, Oskar, Miszczyk, Justyna, Tomanek, Boguslaw, Depciuch, Joanna
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Language:English
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Drug delivery systems
Drugs
Ethylenediaminetetraacetic acid
Magnetite
Methods
Pancreatic cancer
Vehicles
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container_issue 19
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container_title Materials
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creator Pawlik, Piotr
Błasiak, Barbara
Pruba, Marcin
Miaskowski, Arkadiusz
Moraczyński, Oskar
Miszczyk, Justyna
Tomanek, Boguslaw
Depciuch, Joanna
description This work is aimed at presenting a novel aerosol-based technique for the synthesis of magnetite nanoparticles (Fe[sub.3]O[sub.4] NPs) and to assess the potential medical application of their dispersions after being coated with TEA-oleate. Refinement of the processing conditions led to the formation of monodispersed NPs with average sizes of ∼5–6 nm and narrow size distribution (FWHM of ∼3 nm). The NPs were coated with Triethanolammonium oleate (TEA-oleate) to stabilize them in water dispersion. This allowed obtaining the dispersion, which does not sediment for months, although TEM and DLS studies have shown the formation of small agglomerates of NPs. The different behaviors of cancer and normal cell lines in contact with NPs indicated the diverse mechanisms of their interactions with Fe[sub.3]O[sub.4] NPs. Furthermore, the studies allowed assessment of the prospective theranostic application of magnetite NPs obtained using the aerosol-based technique, particularly magnetic hyperthermia and magnetic resonance imaging (MRI).
doi_str_mv 10.3390/ma16196483
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subjects Drug delivery systems
Drugs
Ethylenediaminetetraacetic acid
Magnetite
Methods
Pancreatic cancer
Vehicles
title Fe[sub.3]O[sub.4] Magnetic Nanoparticles Obtained by the Novel Aerosol-Based Technique for Theranostic Applications
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