Genotoxic Effects of New Azoloazine Derivatives with Antitumor Activity in MCF-7 Tumor Cell Culture

The genotoxic properties of three new azoloazine derivatives (azoloazines 1 – 3 ) exhibiting cytotoxic activity were studied in an in vitro experiment using MCF-7 human breast cancer cell culture. Acomparison of the effects of azoloazines 1 – 3 at doses of 1/2, 1/10, and 1/50 of IC 50 with those of...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutical chemistry journal 2023-09, Vol.57 (6), p.822-827
Main Authors: Al-Humain, A. H., Speranskiy, D. L., Rybalkina, O. Yu, Sadchikova, E. V., Buldakov, M. A., Frolova, A. A., Cherdyntseva, N. V., Udut, V. V.
Format: Article
Language:English
Subjects:
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The genotoxic properties of three new azoloazine derivatives (azoloazines 1 – 3 ) exhibiting cytotoxic activity were studied in an in vitro experiment using MCF-7 human breast cancer cell culture. Acomparison of the effects of azoloazines 1 – 3 at doses of 1/2, 1/10, and 1/50 of IC 50 with those of epirubicin at the same doses on the main indicators of damage to the genetic apparatus of the cells revealed that the studied compounds had the greatest toxic effect on DNAat a dose 1/10 of IC 50 . The genotoxicity of azoloazines 1 – 3 at a dose 1/10 of IC 50 was shown to exceed that of epirubicin.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-023-02955-5