UV/H[sub.2]O[sub.2]-Degraded Polysaccharides from ISargassum fusiforme/I: Purification, Structural Properties, and Anti-Inflammatory Activity

The main purpose of this study was to analyze the structural properties and anti-inflammatory activity of the purified fractions derived from UV/H[sub.2] O[sub.2] -degraded polysaccharides from Sargassum fusiforme. Results indicated that two fractions with different monosaccharide compositions and m...

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Bibliographic Details
Published in:Marine drugs 2023-10, Vol.21 (11)
Main Authors: Chang, Shiyuan, Chen, Xiaoyong, Chen, Yifan, You, Lijun, Hileuskaya, Kseniya
Format: Article
Language:English
Subjects:
Chemical properties
Health aspects
Polysaccharides
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Summary:The main purpose of this study was to analyze the structural properties and anti-inflammatory activity of the purified fractions derived from UV/H[sub.2] O[sub.2] -degraded polysaccharides from Sargassum fusiforme. Results indicated that two fractions with different monosaccharide compositions and morphological characteristics, PT-0.25 (yield 39.5%) and PT-0.5 (yield 23.9%), were obtained. The average molecular weights of PT-0.25 and PT-0.5 were 14.52 kDa and 22.89 kDa, respectively. In addition, PT-0.5 exhibited better anti-inflammatory activity with a clear dose dependence. The mechanism was associated with the inhibition of LPS-activated Toll-like receptor 4-mediated inflammatory pathways in RAW 264.7 cells. The results showed that PT-0.5 was a complex polysaccharide mainly composed of 4-Fucp, t-Manp, 6-Galp, t-Fucp, and 3,4-GlcAp. These results would provide theoretical support for studying the structural properties and biological activities of UV/H[sub.2] O[sub.2] -degraded polysaccharides.
ISSN:1660-3397
1660-3397
DOI:10.3390/md21110561