Protocol for a randomized clinical trial comparing the efficacy of Structured Diet

Autism spectrum disorders (ASD) have a lifelong impact on behavior, communication, cognitive function, education, physical functioning, and personal, or social life. Separate studies suggest, Therapeutic and dietary interventions are effective to some extent in managing these issues. No study integr...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2023-11, Vol.18 (11), p.e0292326
Main Authors: Akter, Ruksana, Urme, Nadia Afrin, Hossain, K. M. Amran, Hossain, Tofajjal, Ahammad, Shameem, Yeasmin, Mst. Hosneara, Hossain, Md. Zahid, Parvin, Rashida, Hossain, Md. Sohrab, Zahid, Md. Ashrafuzzaman
Format: Article
Language:English
Subjects:
Autism
Clinical trials
Comparative analysis
Diet
Diet therapy
Health aspects
Malnutrition
Malnutrition in children
Medical nutrition therapy
Medical research
Medicine, Experimental
Social aspects
Teenagers
Testing
Youth
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Autism spectrum disorders (ASD) have a lifelong impact on behavior, communication, cognitive function, education, physical functioning, and personal, or social life. Separate studies suggest, Therapeutic and dietary interventions are effective to some extent in managing these issues. No study integrated the nutrition and therapeutic approaches and examined the outcome on disease severity, overall health, and behavioral status in ASD. The proposed study is designed to evaluate the combined effect of regular therapy (RT) and structured diet (SD) compared to the usual diet (UD) for Adolescents with ASD. The proposed study will be a randomized clinical trial (RCT) with the assessor, therapist, and participants blinded to group allocation. Seventy ASD children with malnutrition will be enrolled in two different facilities of the Centre for the Rehabilitation of the Paralysed (CRP) between January 2023 and June 2023. Participants will be enrolled through a hospital-based randomization process from a population-based screening dataset, and with a concealed group allocation to either RT+ SD or RT+ UD group with a 1:1 ratio. The outcome measures are the Childhood Autism Rating Scale as per DSM-5 to determine the severity of ASD, Mid-upper arm circumference (MUAC), and BMI for nutritional status, and Gilliam Autism Rating Scale (GARS-2) to assess the behavioral status. Post-test will be performed after 12 weeks of intervention, and Follow-up will be taken after 6 months of post-test.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0292326