HEADACHE FACIAL PAIN SECTION Profiling migraine patients according to clinical and psychophysical characteristics: a cluster analysis approach

Aim: This study aims to profile migraine patients according clinical and psychophysical characteristics. Method: In this observational study, two cohorts of migraine patients(episodic/chronic) were included. Cohort-1: ictal/perictal phase; Cohort-2: interictal phase. The following variables were ass...

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Published in:Pain medicine (Malden, Mass.) Mass.), 2023-09, Vol.24 (9), p.1046
Main Authors: Antonio, Stefano Di, Arendt-Nielsen, Lars, Ponzano, Marta, Bovis, Francesca, Torelli, Paola, Finocchi, Cinzia, Castaldo, Matteo
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Language:English
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Demographic aspects
Development and progression
Diagnosis
Migraine
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container_issue 9
container_start_page 1046
container_title Pain medicine (Malden, Mass.)
container_volume 24
creator Antonio, Stefano Di
Arendt-Nielsen, Lars
Ponzano, Marta
Bovis, Francesca
Torelli, Paola
Finocchi, Cinzia
Castaldo, Matteo
description Aim: This study aims to profile migraine patients according clinical and psychophysical characteristics. Method: In this observational study, two cohorts of migraine patients(episodic/chronic) were included. Cohort-1: ictal/perictal phase; Cohort-2: interictal phase. The following variables were assessed: headache frequency; disability; cervical active range of motion(AROM) in flexion, extension, right/left lateral flexion, right/left rotation; pressure-pain threshold(PPT) over: temporalis, two cervical areas(C1/C4 vertebral segments), and two distal painfree areas(hand/leg). Cluster analysis was performed using the K-means algorithm. Differences across clusters were investigated. Results: Cohort-1: 100 patients were included, and two clusters were identified. Cluster-1.1 (19%), Cluster-1.2 (81%). Cluster 1.1 had a higher percentage of men (P=.037) and higher disability (P= .003) compared to Clusters 1.2. Cluster 1.2 had reduced AROM in flexion, extension, and left/right lateral flexion (P
doi_str_mv 10.1093/pm/pnad048
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Method: In this observational study, two cohorts of migraine patients(episodic/chronic) were included. Cohort-1: ictal/perictal phase; Cohort-2: interictal phase. The following variables were assessed: headache frequency; disability; cervical active range of motion(AROM) in flexion, extension, right/left lateral flexion, right/left rotation; pressure-pain threshold(PPT) over: temporalis, two cervical areas(C1/C4 vertebral segments), and two distal painfree areas(hand/leg). Cluster analysis was performed using the K-means algorithm. Differences across clusters were investigated. Results: Cohort-1: 100 patients were included, and two clusters were identified. Cluster-1.1 (19%), Cluster-1.2 (81%). Cluster 1.1 had a higher percentage of men (P=.037) and higher disability (P= .003) compared to Clusters 1.2. Cluster 1.2 had reduced AROM in flexion, extension, and left/right lateral flexion (P&lt;.037), and lower PPT value in all areas (P&lt; .001) compared to Cluster 1.1. Cohort-2: 98 patients were included and three clusters were identified. Cluster-2.1(18%), Cluster-2.2(45%), and Cluster-2.3(37%). Cluster-2.1 had a higher percentage of men compared to clusters-2.2 and 2.3 (P=.009). Cluster-2.3 had higher headache frequency, and disability compared to Cluster-2.2 (P &lt; .006), and higher disability compared to Cluster-2.1 (P=.010). Cluster-2.3 had reduced AROM in all directions compared to Clusters-2.1 and 2.2 (P&lt;.029). Clusters-2.2 and 2.3 have lower PPT values in all areas compared to Cluster-1.1 (P &lt; .001). Conclusion: In the Ictal/perictal phase, two clusters were identified according to clinical and psychophysical characteristics, with one group showing no psychophysical impairment and one with increased pain-sensitivity and cervical musculoskeletal-dysfunctions. In the interictal phase, three clusters could be identified, with one group showing no psychophysical impairment, one increased pain-sensitivity, and one increased pain sensitivity and cervical musculoskeletal-dysfunctions. Keywords: episodic migraine; chronic migraine; phenotype; precision medicine; pain sensitivity; musculoskeletal dysfunction</description><identifier>ISSN: 1526-2375</identifier><identifier>DOI: 10.1093/pm/pnad048</identifier><language>eng</language><publisher>Oxford University Press</publisher><subject>Demographic aspects ; Development and progression ; Diagnosis ; Migraine</subject><ispartof>Pain medicine (Malden, Mass.), 2023-09, Vol.24 (9), p.1046</ispartof><rights>COPYRIGHT 2023 Oxford University Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Antonio, Stefano Di</creatorcontrib><creatorcontrib>Arendt-Nielsen, Lars</creatorcontrib><creatorcontrib>Ponzano, Marta</creatorcontrib><creatorcontrib>Bovis, Francesca</creatorcontrib><creatorcontrib>Torelli, Paola</creatorcontrib><creatorcontrib>Finocchi, Cinzia</creatorcontrib><creatorcontrib>Castaldo, Matteo</creatorcontrib><title>HEADACHE FACIAL PAIN SECTION Profiling migraine patients according to clinical and psychophysical characteristics: a cluster analysis approach</title><title>Pain medicine (Malden, Mass.)</title><description>Aim: This study aims to profile migraine patients according clinical and psychophysical characteristics. Method: In this observational study, two cohorts of migraine patients(episodic/chronic) were included. Cohort-1: ictal/perictal phase; Cohort-2: interictal phase. The following variables were assessed: headache frequency; disability; cervical active range of motion(AROM) in flexion, extension, right/left lateral flexion, right/left rotation; pressure-pain threshold(PPT) over: temporalis, two cervical areas(C1/C4 vertebral segments), and two distal painfree areas(hand/leg). Cluster analysis was performed using the K-means algorithm. Differences across clusters were investigated. Results: Cohort-1: 100 patients were included, and two clusters were identified. Cluster-1.1 (19%), Cluster-1.2 (81%). Cluster 1.1 had a higher percentage of men (P=.037) and higher disability (P= .003) compared to Clusters 1.2. Cluster 1.2 had reduced AROM in flexion, extension, and left/right lateral flexion (P&lt;.037), and lower PPT value in all areas (P&lt; .001) compared to Cluster 1.1. Cohort-2: 98 patients were included and three clusters were identified. Cluster-2.1(18%), Cluster-2.2(45%), and Cluster-2.3(37%). Cluster-2.1 had a higher percentage of men compared to clusters-2.2 and 2.3 (P=.009). Cluster-2.3 had higher headache frequency, and disability compared to Cluster-2.2 (P &lt; .006), and higher disability compared to Cluster-2.1 (P=.010). Cluster-2.3 had reduced AROM in all directions compared to Clusters-2.1 and 2.2 (P&lt;.029). Clusters-2.2 and 2.3 have lower PPT values in all areas compared to Cluster-1.1 (P &lt; .001). Conclusion: In the Ictal/perictal phase, two clusters were identified according to clinical and psychophysical characteristics, with one group showing no psychophysical impairment and one with increased pain-sensitivity and cervical musculoskeletal-dysfunctions. In the interictal phase, three clusters could be identified, with one group showing no psychophysical impairment, one increased pain-sensitivity, and one increased pain sensitivity and cervical musculoskeletal-dysfunctions. 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Method: In this observational study, two cohorts of migraine patients(episodic/chronic) were included. Cohort-1: ictal/perictal phase; Cohort-2: interictal phase. The following variables were assessed: headache frequency; disability; cervical active range of motion(AROM) in flexion, extension, right/left lateral flexion, right/left rotation; pressure-pain threshold(PPT) over: temporalis, two cervical areas(C1/C4 vertebral segments), and two distal painfree areas(hand/leg). Cluster analysis was performed using the K-means algorithm. Differences across clusters were investigated. Results: Cohort-1: 100 patients were included, and two clusters were identified. Cluster-1.1 (19%), Cluster-1.2 (81%). Cluster 1.1 had a higher percentage of men (P=.037) and higher disability (P= .003) compared to Clusters 1.2. Cluster 1.2 had reduced AROM in flexion, extension, and left/right lateral flexion (P&lt;.037), and lower PPT value in all areas (P&lt; .001) compared to Cluster 1.1. Cohort-2: 98 patients were included and three clusters were identified. Cluster-2.1(18%), Cluster-2.2(45%), and Cluster-2.3(37%). Cluster-2.1 had a higher percentage of men compared to clusters-2.2 and 2.3 (P=.009). Cluster-2.3 had higher headache frequency, and disability compared to Cluster-2.2 (P &lt; .006), and higher disability compared to Cluster-2.1 (P=.010). Cluster-2.3 had reduced AROM in all directions compared to Clusters-2.1 and 2.2 (P&lt;.029). Clusters-2.2 and 2.3 have lower PPT values in all areas compared to Cluster-1.1 (P &lt; .001). Conclusion: In the Ictal/perictal phase, two clusters were identified according to clinical and psychophysical characteristics, with one group showing no psychophysical impairment and one with increased pain-sensitivity and cervical musculoskeletal-dysfunctions. In the interictal phase, three clusters could be identified, with one group showing no psychophysical impairment, one increased pain-sensitivity, and one increased pain sensitivity and cervical musculoskeletal-dysfunctions. Keywords: episodic migraine; chronic migraine; phenotype; precision medicine; pain sensitivity; musculoskeletal dysfunction</abstract><pub>Oxford University Press</pub><doi>10.1093/pm/pnad048</doi></addata></record>
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subjects Demographic aspects
Development and progression
Diagnosis
Migraine
title HEADACHE FACIAL PAIN SECTION Profiling migraine patients according to clinical and psychophysical characteristics: a cluster analysis approach
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