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NEUROPATHIC PAIN SECTION: Central sensitization in CRPS patients with widespread pain: a cross-sectional study

Objective: Widespread pain hypersensitivity and enhanced temporal summation of pain (TSP) are commonly reported in patients with complex regional pain syndrome (CRPS) and discussed as proxies for central sensitization. This study aimed to directly relate such signs of neuronal hyperexcitability to t...

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Bibliographic Details
Published in:Pain medicine (Malden, Mass.) Mass.), 2023-08, Vol.24 (8), p.974
Main Authors: Schoenmacker, Iara De, Mollo, Anna, Scheuren, Paulina Simonne, Sirucek, Laura, Brunner, Florian, Schweinhardt, Petra, Curt, Armin, Rosner, Jan, Hubli, Michele
Format: Article
Language:English
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Summary:Objective: Widespread pain hypersensitivity and enhanced temporal summation of pain (TSP) are commonly reported in patients with complex regional pain syndrome (CRPS) and discussed as proxies for central sensitization. This study aimed to directly relate such signs of neuronal hyperexcitability to the pain phenotype of CRPS patients. Methods: Twenty-one CRPS patients and 20 healthy controls (HC) were recruited. The pain phenotype including spatial pain extent (assessed in % body surface) and intensity were assessed and related to widespread pain hypersensitivity, TSP, and psychological factors. Quantitative sensory testing (QST) was performed in the affected, the contralateral and a remote (control) area. Results: CRPS patients showed decreased pressure pain thresholds in all tested areas (affected: t(34) =4.98, P
ISSN:1526-2375
DOI:10.1093/pm/pnad040