The effects of Leishmania RNA virus 2

Cutaneous Leishmaniasis (CL) is a parasitic disease with diverse outcomes. Clinical diversity is influenced by various factors such as Leishmania species and host genetic background. The role of Leishmania RNA virus (LRV), as an endosymbiont, is suggested to not only affect the pathogenesis of Leish...

Full description

Saved in:
Bibliographic Details
Published in:BMC microbiology 2023-12, Vol.23 (1)
Main Authors: Mirabedini, Zahra, Mirjalali, Hamed, Kazemirad, Elham, Khamesipour, Ali, Samimirad, Katayoun, Koosha, Mona, Saberi, Reza, Rahimi, Hanieh Mohammad, Mohebali, Mehdi, Hajjaran, Homa
Format: Article
Language:English
Subjects:
Biological markers
Development and progression
Gene expression
Genetic aspects
Inflammation
Leishmaniasis, Cutaneous
Parasitological research
RNA viruses
Virulence (Microbiology)
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cutaneous Leishmaniasis (CL) is a parasitic disease with diverse outcomes. Clinical diversity is influenced by various factors such as Leishmania species and host genetic background. The role of Leishmania RNA virus (LRV), as an endosymbiont, is suggested to not only affect the pathogenesis of Leishmania, but also impact host immune responses. This study aimed to investigate the influence of LRV2 on the expression of a number of virulence factors (VFs) of Leishmania and pro-inflammatory biomarkers. The expression of GP63, HSP83, and MPI revealed up-regulation in LRV2 + isolates compared to LRV2- isolates. The expression of the pro-inflammatory biomarkers including NLRP3, IL1[beta], and IL18 genes in LRV2- were higher than LRV2 + isolates. This finding suggests that LRV2 + may have a probable effect on the Leishmania VFs and pro-inflammatory biomarkers in the human macrophage model.
ISSN:1471-2180
1471-2180
DOI:10.1186/s12866-023-03140-0