Association between Serum [alpha]-Klotho Levels and Behcet Disease

Background: Endothelial dysfunction (ED) has a well-known role in promoting vascular inflammation in Behget disease (BD). [alpha]-klotho is involved in regulation of endothelial function, and its reduction has been reported to be associated with ED. Objective: To assess serum [alpha]-klotho in patie...

Full description

Saved in:
Bibliographic Details
Published in:Laboratory medicine 2023-09, Vol.54 (5), p.469
Main Authors: Nakhjavani, Mohammad Reza Jafari, Ghorbanihaghjo, Amir, Mahdavi, Aida Malek, Nemati, Negin, Rashtchizadeh, Nadereh, Azar, Sima Abedi, Khabbazi, Allireza
Format: Article
Language:English
Subjects:
Endothelium
Inflammation
Medical research
Medicine, Experimental
Proteins
Superoxide
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Endothelial dysfunction (ED) has a well-known role in promoting vascular inflammation in Behget disease (BD). [alpha]-klotho is involved in regulation of endothelial function, and its reduction has been reported to be associated with ED. Objective: To assess serum [alpha]-klotho in patients with BD, compared with healthy control individuals. Methods: In a cross-sectional study, 55 patients with BD and 30 age-and sex-matched healthy controls were enrolled, and their serum levels of [alpha]-klotho were measured. Results: Common clinical symptoms in patients with BD were oral aphthous ulcers, uveitis, and genital ulcers. Median (IQR) serum [alpha]-klotho levels in the BD and control groups were 0.30 (0.20-0.70) and 1.00 (0.70-2.52) ng/mL, respectively. The difference was statistically significant (P = .005). No significant correlation was observed between serum [alpha]-klotho and age (r= 0.194; P = .14). Serum [alpha]-klotho levels in patients with uveitis were significantly lower. Conclusion: [alpha]-klotho may have a role in the pathogenesis of ED and is a potential biomarker for uveitis in BD. Keywords: Behget disease, [alpha]-klotho, klotho proteins, endothelial dysfunction, vasculitis, superoxide dismutase 2
ISSN:0007-5027
DOI:10.1093/labmed/lmad46