Incretin Hypersecretion in Gestational Diabetes Mellitus

Context: Incretins are crucial stimulators of insulin secretion following food intake. Data on incretin secretion and action during pregnancy are sparse. Objective: The aim of the study was to investigate the incretin response during an oral glucose tolerance test (OGTT) in pregnant women with and w...

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Published in:The journal of clinical endocrinology and metabolism 2022-06, Vol.107 (6), p.e2425
Main Authors: Fritsche, Louise, Heni, Ma, Eckstein, Sabine S, Hummel, Julia, Schurmann, Anette, Haring, Hans-Ulrich, Preibl, Hubert, Birkenfeld, Andreas L, Peter, Andreas, Fritsche, Andreas, Wagner, Robert
Format: Article
Language:English
Subjects:
Analysis
Aprotinin
Dextrose
Diabetes in pregnancy
Ethylenediaminetetraacetic acid
Glucagon
Glucose
Glucose tolerance tests
Insulin
Pharmaceutical industry
Pregnant women
Sitagliptin
Type 2 diabetes
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Summary:Context: Incretins are crucial stimulators of insulin secretion following food intake. Data on incretin secretion and action during pregnancy are sparse. Objective: The aim of the study was to investigate the incretin response during an oral glucose tolerance test (OGTT) in pregnant women with and without gestational diabetes mellitus (GDM). Design: We analyzed data from the ongoing observational PREG study (NCT 04270578). Setting: The study was conducted at the University HospitalTubingen. Participants: We examined 167 women (33 with GDM) during gestational week 27 [+ or -] 2.2. Intervention: Subjects underwent 5-point OGTT with a 75-g glucose load. Main outcome measures: We assessed insulin secretion and levels of total glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP), glicentin, and glucagon during OGTT. Linear regression was used to analyze the relation of GLP-1 and glucose with insulin secretion and the association of incretin levels on birth outcome. Results: Insulin secretion was significantly lower in women with GDM (P< 0.001). Postload GLP-1 and GIP were ~20% higher in women with GDM (all P
ISSN:0021-972X
DOI:10.1210/clinem/dqac095