Retrospective evaluation of obstetric processes in patients with Behcet's disease/ Behcet hastaligi ile takipli hastalarda obstetrik sureclerin retrospektif degerlendirmesi

• Published in: Journal of Turkish Society for Rheumatology 2023-11, Vol.15 (3), p.149
• Main Authors: Deniz, Rabia, Deniz, Ferdanur, Kalem, Gizem Sirin, Ozgur, Duygu Sevinc, Akkuzu, Gamze, Karaalioglu, Bilgin, Yildirim, Fatih, Ince, Burak, Kalkan, Kubra, Guzelant, Gul, Bes, Cemal
• Format: Article
• Language: English
• Subjects: Adalimumab; Analysis; Care and treatment; Complications and side effects; Diagnosis; Genetic disorders; Medical records; Mothers; Obstetrics; Patient outcomes; Pregnancy; Pregnant women
• ISSN: 2651-2653
• DOI: 10.4274/raed.galenos.2023.83803

Objective: Behcet's disease (BD) is a multisystemic vasculitis affecting both gender and usually diagnosed in reproductive age. In this study, we aimed to investigate the relation between BD and pregnancy on the both maternal and fetal aspects. Methods: In this retrospective, single-center, descriptive study we analysed total 61 pregnancies of 18 BD patients. Clinical and demographic data were obtained from patients records regarding maternal age, disease history, obstetric history, pregnancy outcome and both maternal and fetal complications. To prevent recall bias, only the recent pregnancy of each patient were evaluated for disease activity and use or revision of medications during pregnancy. Results: The median age of the patients at diagnosis was 25 and first pregnancy age was 24.5 years. The median duration of BD during pregnancy was 3.5 years. Only one patient needed to in vitro fertilization to become pregnant. All patients were in remission before recent pregnancy. Fourteen (77.8%) patients had no symptoms during recent pregnancy, while remaining 3 patients had mucocutaneous and 1 patient had vascular activity. The rate of live birth was 74.1%, abortus was 20.7%, preterm labor was 11.6%, pre-eclampsia was 5.6%, and no congenital fetal abnormality was observed. Conclusion: Except for vascular complications, no major organ involvement was described during pregnancy. Higher miscarriage rates were observed compared the healthy pregnancyies. Obstetric complications were not increased and fetal outcomes were not negatively affected by BD. BD is not a contraindication for the onset of pregnancy but control of disease activity before pregnancy, revision of potentially teratogenic agents, and frequent follow-up of patients in view of potential complications are important to minimize risks. Keywords: Behcet's disease, pregnancy, maternal morbidity, obstetric complications Amac: Behcet hastaligi (BH), her iki cinsiyeti de etkileyen ve genellikle ureme caginda tani konulan multisistemik bir vaskulittir. Bu calismada, BH ile gebelik arasindaki iliskiyi hem maternal hem de fetal acidan arastirmayi amacladik. Yontem: Bu retrospektif, tek merkezli, tanimlayici calismada 18 Behcet hastasinin toplam 61 gebeligi incelendi. Klinik ve demografik veriler, hasta yasi, hastalik oykusu, obstetrik oyku, gebelik sonucu ve hem maternal hem de fetal komplikasyonlara iliskin kayitlardan elde edildi. Hatirlama yanliligini onlemek icin, her hastanin yalnizca son gebeligi, hastali