Modeling Mediated Crossover Acute and Subacute Damage to the Pulmonary System During Systemic de Administracion de Bleomicina a Ratones para Probar el Posible Efecto Terapeutico de los Polifenoles

The potential anti-inflammatory and antifibrotic activity of polyphenolic extracts of blueberry and grape was evaluated in a mouse model of lung damage induced by subcutaneous administration of bleomycin. The results of testing the polyphenolic extracts on two different systemic administration varia...

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Bibliographic Details
Published in:International journal of morphology 2023-11, Vol.41 (6), p.1837
Main Authors: Shulgau, Zarina, Kamyshanskiy, Yevgeniy, Sergazy, Shynggys, Zhulikeyeva, Aigerim, Urazbayeva, Assel, Makhmutova, Ainura, Bokebayev, Zhanybek, Gulyayev, Alexandre, Ramankulov, Yerlan
Format: Article
Language:Spanish
Subjects:
Analysis
Bleomycin
Health aspects
Polyphenols
Online Access:Get full text
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Summary:The potential anti-inflammatory and antifibrotic activity of polyphenolic extracts of blueberry and grape was evaluated in a mouse model of lung damage induced by subcutaneous administration of bleomycin. The results of testing the polyphenolic extracts on two different systemic administration variants of bleomycin (intraperitoneal and subcutaneous) were compared. It was found that regardless of the method of bleomycin administration, indirect cross-acute and subacute damage to the pulmonary system was observed. Both patterns exhibited the same prevalence and severity. The administration of polyphenolic extracts of blueberry and grape to mice resulted in a significant decrease in theseverity of acute and subacute patterns of lung damage, suggesting their protective properties for the microcirculatory bed and a pronounced anti-inflammatory effect. KEY WORDS: Fibrosis; Bleomycin; Polyphenols; Blueberry extract; Grape extract.
ISSN:0717-9367