Trial design of the MOTheR HDx study: a multicenter, open-label, prospective, randomized study to explore the morbidity and mortality in patients dialyzed with the Theranova HDx in comparison with online hemodiafiltration

Even though hemodialysis is a renal replacement therapy that allows patients with end-stage renal disease to be kept alive, cardiovascular morbidity and mortality are very high. The dialysis membrane where the exchange of uremic toxins between the blood and the dialysis fluid occurs is the key eleme...

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Bibliographic Details
Published in:Clinical Kidney Journal 2023, Vol.16 (11), p.2254
Main Authors: de Sequera, Patricia, Perez-Garcia, Rafael, Vega, Almudena, Martinez-Vaquera, Shaira, Acosta, Jesus Guillermo, Del Valle, Katia Perez, Fernandez-Lucas, Milagros, Garcia-Rubiales, Maria Antonia, Garcia-Herrera, Antonio Luis, Coll, Elisabeth, Merida, Evangelina, Martinez-Miguel, Patricia, Castano, Itziar, Gil-Casares, Beatriz, Garro, Julia, Maduell, Francisco
Format: Report
Language:English
Subjects:
Albumin
Chronic kidney failure
Clinical trials
Colitis
Comparative analysis
Coronary heart disease
Health aspects
Morbidity
Mortality
Permeability
Spain
Stroke (Disease)
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Summary:Even though hemodialysis is a renal replacement therapy that allows patients with end-stage renal disease to be kept alive, cardiovascular morbidity and mortality are very high. The dialysis membrane where the exchange of uremic toxins between the blood and the dialysis fluid occurs is the key element of the hemodialysis procedure. A new generation of membranes, called medium cut-off because they allow the removal of a greater number of medium-sized molecules, have generated a new concept of therapy called expanded HD. The objective of this study is to compare this new therapy with the technique that up to now has shown superiority in terms of survival, online hemodiafiltration.
ISSN:2048-8505
DOI:10.1093/ckj/sfad128