Advanced Taste-Masking Methods of Solid Dosage Forms

One of the main problems in medical practice is the lack of patient adherence to treatment, which is often attributed to the bitterness or sourness of medicines causing discomfort and an aversion during administration, especially in children. Therefore, masking an unpleasant taste is one of the goal...

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Bibliographic Details
Published in:Pharmaceutical chemistry journal 2023-12, Vol.57 (9), p.1494-1498
Main Authors: Bueva, V. V., Blynskaja, E. V., Alekseev, K. V., Minaev, S. V., Eremin, V. A.
Format: Article
Language:English
Subjects:
Drug Synthesis Methods and Manufacturing Technology
Efavirenz
Medicine
Methods
Organic Chemistry
Patient compliance
Pharmacology/Toxicology
Pharmacy
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Summary:One of the main problems in medical practice is the lack of patient adherence to treatment, which is often attributed to the bitterness or sourness of medicines causing discomfort and an aversion during administration, especially in children. Therefore, masking an unpleasant taste is one of the goals of pharmaceutical development. Currently, there are various approaches to improving the taste of oral dosage forms containing bitter or excessively sour pharmaceutical substances. This review covers some of these approaches and their advantages and disadvantages and provides relevant examples of the possible use of each of them.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-023-03015-8