sub.2C]-Adrenergic Receptor Blockade Inhibits Langendorff-Isolated Rat Heart Work

We studied the effect of selective [[alpha].sub.2C]-adrenergic receptor antagonist JP-1302 in concentrations of [10.sup.-9]-[10.sup.-6] M on inotropy, chronotropy, and coronary flow in the Langendorff-isolated rat heart. JP-1302 in all studied concentrations decreased the left-ventricular myocardium...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2023-09, Vol.175 (5), p.612
Main Authors: Zefirov, T.L, Khisamieva, L.I, Khabibrakhmanov, I.I, Ziyatdinova, N.I, Zefirov, A.L
Format: Article
Language:English
Subjects:
Heart
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Summary:We studied the effect of selective [[alpha].sub.2C]-adrenergic receptor antagonist JP-1302 in concentrations of [10.sup.-9]-[10.sup.-6] M on inotropy, chronotropy, and coronary flow in the Langendorff-isolated rat heart. JP-1302 in all studied concentrations decreased the left-ventricular myocardium force contraction, HR, and coronary flow. The maximum inotropic, chronotropic, and vascular effects were observed when the antagonist was applied to the perfused solution in a concentration of [10.sup.-7] M. The least pronounced decrease in the studied parameters was observed at JP-1302 concentrations of [10.sup.-8] and [10.sup.-9] M. The obtained data indicate the participation of this subtype of [[alpha].sub.2]-adrenergic receptors in the regulation of activity of isolated adult rats heart. Key Words: heart; [[alpha].sub.2C]-adrenergic receptor; myocardium; JP-1302; rat
ISSN:0007-4888
DOI:10.1007/s10517-023-05911-1