Tranexamic Acid and Its Application in Oral Surgery. Systematic Review /Acido tranexamico y su aplicacion en cirugia oral. Revision sistematica /Acido tranexamico e sua aplicacao em cirurgia oral. Revisao sistematica

• Published in: Universitas odontológica 2023-01, Vol.42
• Main Authors: Armijos Idrovo, Silvana Graciela, Pesantez Alvarado, Juan Martin, Lafebre Carrasco, Milton Fabricio, Pacheco Carabajo, Luis Adrian
• Format: Article
• Language: Spanish
• Subjects: Okamoto, Shosuke; Okamoto, Utako
• ISSN: 0120-4319
• DOI: 10.11144/Javeriana.uo41.taao

Background: Tranexamic acid (TXA) is a synthetic analogue of lysine, which inhibits fibrinolysis by reducing the conversion of plasminogen into plasmin, thereby promoting the preservation of the clot formed in the operated area and reducing the risk of bleeding. It is eventually used as a complement in oral surgery. Purpose: To analyze the evidence on the effectiveness in hemostasis, appropriate dose, safety margin, benefits, and postoperative evolution of TXA used in oral surgery. Methods: The systematic review was structured from a search tree (PubMed, Google Scholar, ProQuest, and Scopus), with the keywords and Boolean connector: Tranexamic Acid AND Oral Surgery. The search was limited to the English, Portuguese, and Spanish languages; open-access articles; systematic reviews, meta-analyses, randomized clinical trials, and case reports. We established a secondary selection based on the title and abstract of the articles according to the purpose of the study. Findings: The literature reports an efficacy of 80 % of TXA in reducing bleeding risk during and after surgical procedures, which optimizes the procedures. Conclusions: Topical or intravenous TXA in doses not exceeding 20 mg has proven to be effective to reduce the risk of bleeding in oral surgery. Keywords: antifibrinolytic; blood dyscrasias; complications; dentistry; drug therapy; hemorrhage; oral surgery; oral surgical procedures; therapeutics; tranexamic acid Antecedentes: El acido tranexamico (ATX) es un analogo sintetico de la lisina que inhibe la fibrinolisis al reducir la conversion de plasminogeno en plasmina, lo que favorece la preservation del coagulo formado en el area operada y reduce el riesgo de sangrado. Eventualmente se utiliza como complemento en cirugia oral. Objetivo: Analizar la evidencia sobre la efectividad en hemostasia, dosis adecuada, margen de seguridad, beneficios y evolucion postoperatoria de los ATX utilizados en cirugia bucal. Metodos: La revision sistematica se estructuro a partir de un arbol de busqueda (PubMed, Google Academico, ProQuest y Scopus), con las palabras clave y conector booleano: Acido Tranexamico Y Cirugia Oral. La busqueda se limito a los idiomas ingles, portugues y espanol; articulos de acceso abierto; revisiones sistematicas, metanalisis, ensayos clinicos aleatorizados e informes de casos. Se establecio una selection secundaria a partir del titulo y resumen de los articulos segun el proposito del estudio. Hallazgos: La literatura reporta una eficacia