Role of interleukin-32 in cancer progression (Review)

Interleukin (IL)-32 is induced by pro-inflammatory cytokines and promotes the release of inflammatory cytokines. Therefore, it can promote inflammatory responses. The present review article summarized the role of the receptors required for IL-32 action, the biological function of IL-32 and its mecha...

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Bibliographic Details
Published in:Oncology letters 2024-02, Vol.27 (2), p.1
Main Authors: Meng, Danyang, Dong, Hang, Wang, Chennan, Zang, Rongjia, Wang, Jianjie
Format: Article
Language:English
Subjects:
Cancer
Colorectal cancer
Development and progression
Interleukins
Lung cancer
Online Access:Get full text
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Summary:Interleukin (IL)-32 is induced by pro-inflammatory cytokines and promotes the release of inflammatory cytokines. Therefore, it can promote inflammatory responses. The present review article summarized the role of the receptors required for IL-32 action, the biological function of IL-32 and its mechanism of action in tumors. Moreover, it assessed the significance of aberrant IL-32 expression in associated diseases and analyzed the effects of IL-32 on four key types of cancer: Colorectal, gastric, breast and lung. However, the mechanism of action of IL-32 needs to be further demonstrated by assessing the role of this cytokine in cancer to elucidate novel and reliable targets for future cancer treatments. Key words: interleukin-32, colorectal cancer, gastric cancer, breast cancer, lung cancer
ISSN:1792-1074
DOI:10.3892/01.2023.14187