Efficiency and reliability of serum hepcidin level measurement in evaluation of disease activation in patients with ulcerative colitis/ Ulseratif kolitli hastalarda serum hepsidin duzeyi olcumunun hastalik aktivasyonunu degerlendirmedeki etkinligi ve guvenirligi

Purpose: The study is to examine the relationship between hepcidin and inflammation markers and disease severity. Materials and methods: Hepcidin levels are determined in 108 Ulcerative Colitis patients and 56 control subjects, a total of 164 subjects, equally active and in remission. Correlations b...

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Bibliographic Details
Published in:Pamukkale Medical Journal 2024-01, Vol.17 (1), p.33
Main Authors: Kasikci, Efe Emre, Celik, Mustafa, Akpinar, Kadriye
Format: Article
Language:English
Subjects:
Blood
Diagnosis
Inflammation
Medical examination
Ulcerative colitis
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Summary:Purpose: The study is to examine the relationship between hepcidin and inflammation markers and disease severity. Materials and methods: Hepcidin levels are determined in 108 Ulcerative Colitis patients and 56 control subjects, a total of 164 subjects, equally active and in remission. Correlations between hepcidin levels and Age, Gender, ESR, CRP, WBC Hb levels are determined in the data. The relationship between hepcidin level of active UC patients and Age, Gender, ESR, CRP, WBC, Hb, Truelove-Witts score and Mayo score is evaluated by regression analysis, Results: ESR, CRP and Hepcidin levels in the Active Ulcerative Colitis group are statistically significantly higher than in the remission and control groups; ESR, CRP, Hepcidin levels are found to be statistically significantly higher in the entire ulcerative colitis group compared to the control group. In addition, a statistically significant positive correlation is found between the hepcidin level and the Truelove Witts score and the Mayo score in the AUC group (p
ISSN:1309-9833
DOI:10.31362/patd.1267610