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Metabolic responses, PPAR-[gamma] and TNF-[alpha] gene expression in type2 diabetic rats subsequent vanadyl sulfate treatment

Vanadyl sulfate (VS), is a component of some food supplements and experimental drugs. This study was carried out to present a novel method for induction of Type 2 diabetes in rats, then for the first time in literature, for evaluating the effect of VS on metabolic parameters and gene expression, sim...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2024-01, Vol.37 (1), p.79
Main Authors: Aghadavod, Esmat, Manteghie, Nastaran, Taghizadeh, Mohsen, Talaei, Seyyed Alireza, Mirhashemi, Seyyed Mehdi
Format: Article
Language:English
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Summary:Vanadyl sulfate (VS), is a component of some food supplements and experimental drugs. This study was carried out to present a novel method for induction of Type 2 diabetes in rats, then for the first time in literature, for evaluating the effect of VS on metabolic parameters and gene expression, simultaneously. 40 male wistar rats were distributed between the four groups, equally. High fat diet and fructose were used for diabetes induction. Diabetic rats treated by two different dose of VS for 12 weeks. Metabolic profiles were evaluated by commercial available kits and gene expression were assayed by real time-PCR. Compared to controls, in non-treated diabetic rats, weight, glucose, triglyceride, total cholesterol, insulin and insulin resistance were increased significantly (p-value
ISSN:1011-601X
DOI:10.36721/PJPS.2024.37.1.REG.079-084.1