Phenotypic and Genotypic Drug Resistance of IMycobacterium tuberculosis/I Strains Isolated from HIV-Infected Patients from a Third-Level Public Hospital in Mexico

Background: Drug-resistant tuberculosis (TB) is associated with higher mortality rates in patients with human immunodeficiency virus (HIV). In Mexico, the number of deaths due to TB among the HIV-positive population has tripled in recent years. Methods: Ninety-three Mycobacterium tuberculosis strain...

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Bibliographic Details
Published in:Pathogens (Basel) 2024-01, Vol.13 (2)
Main Authors: Valencia-Trujillo, Daniel, Avila-Trejo, Amanda Marineth, García-Reyes, Rocío Liliana, Narváez-Díaz, Luis, Mújica-Sánchez, Mario Alberto, Helguera-Repetto, Addy Cecilia, Becerril-Vargas, Eduardo, Mata-Miranda, Mónica Maribel, Rivera-Gutiérrez, Sandra, Cerna-Cortés, Jorge Francisco
Format: Article
Language:English
Subjects:
Analysis
Care and treatment
Complications and side effects
Diagnosis
HIV (Viruses)
Phenotype
Tuberculosis
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Summary:Background: Drug-resistant tuberculosis (TB) is associated with higher mortality rates in patients with human immunodeficiency virus (HIV). In Mexico, the number of deaths due to TB among the HIV-positive population has tripled in recent years. Methods: Ninety-three Mycobacterium tuberculosis strains isolated from the same number of HIV-infected patients treated in a public hospital in Mexico City were studied to determine the drug resistance to first- and second-line anti-TB drugs and to identify the mutations associated with the resistance. Results: Of the 93 patients, 82.7% were new TB cases, 86% were male, and 73% had extrapulmonary TB. Most patients (94%) with a CD4 T-lymphocyte count
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens13020098