Constituents of IChimaphila japonica/I and Their Diuretic Activity

Three new phenols (1–3), one new cyclohexanol (4), two known phenols (5–6), and six known flavonoids (7–12) were isolated from the n-butanol of the 75% ethanol extract of all plants of Chimaphila japonica Miq. Among them, compound 5 was named and described in its entirety for the first time, and com...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2024-02, Vol.29 (5)
Main Authors: Yu, Yue, Hu, Deri, Liu, Jinze, Wu, Chenghao, Sun, Yuhong, Lang, Mingyue, Han, Xuan, Kang, Dongzhou, Min, Jun Zhe, Cui, Hong, Zheng, Mingshan
Format: Article
Language:English
Subjects:
Alcohol industry
Bioflavonoids
Cyclohexanol
Flavones
Flavonoids
Hydrochlorothiazide
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Summary:Three new phenols (1–3), one new cyclohexanol (4), two known phenols (5–6), and six known flavonoids (7–12) were isolated from the n-butanol of the 75% ethanol extract of all plants of Chimaphila japonica Miq. Among them, compound 5 was named and described in its entirety for the first time, and compounds 9 and 10 were reported in C. japonica for the first time. The structures of all compounds were confirmed using a comprehensive analysis of 1D and 2D NMR and HRESIMS data. Biological results show that compounds 4, 7, and 11 exhibited potent diuretic activity. The modes of interaction between the selected compounds and the target diuretic-related WNK1 kinase were investigated in a preliminary molecular docking study. These results provided insight into the chemodiversity and potential diuretic activities of metabolites in C. japonica.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules29051092