Differences in Muscle Strength Performance According to the Genotypes of the rs4646994 Polymorphism of the ACE Gene in a Sedentary Population/Diferencias en el Rendimiento de la Fuerza Muscular Segun los Genotipos del Polimorfismo rs4646994 del Gen ACE en una Poblacion Sedentaria

• Published in: International journal of morphology 2024-03, Vol.42 (2), p.227
• Main Authors: Molina-Gutierrez, Nacim, Flores-Quezada, Mauricio, Contreras-Montero, Cintia, Valles, Alejandro Pacheco
• Format: Article
• Language: Spanish
• ISSN: 0717-9367

The angiotensin converting enzyme gene (ACE) has been associated with endurance and strength performance through its I/D polymorphism. Nevertheless, contradictory results exist between different populations. In this context, the purpose of this research was to determine the influence of the I/D polymorphism of the ACE gene on muscle strength in a sedentary Chilean sample. In this study 102 healthy male students (21.3 [+ or -] 2.2 years) completed the assessment. I/D genotyping, cardiovascular, anthropometric, grip strength and knee extensor peak strength were evaluated. The ACE polymorphism frequency was: II, 33.3 %; ID, 46.1 %; DD, 20.6 %. The results showed significant differences and large effect size in maximum (p = 0.004; d = 0.85) and relative handgrip strength (p = 0.004; d = 0.9) between genotype II vs DD. No difference was found for maximal or relative knee extensor strength between groups (p = 0.74), showing a low effect size (d = 0.20). In conclusion, this study provides insights into the role of the ACE gene in muscle strength and highlights the importance of investigating genetic variants in sedentary populations to better understand strength performance.