Effective Inhibition of TNF-[alpha]/mTOR Axis-Mediated Liver Inflammation and Fibrosis Induced by TAA Using a Combination of Metformin and Resveratrol in Association with the Inhibition of the Profibrotic Gene and Protein Expression/Inhibicion Efectiva de la Inflamacion Hepatica Mediada por el Eje TNF-[alpha]/mTOR y la Fibrosis Inducida por TAA Utilizando una Combinacion de Metformina y Resveratrol en Asociacion con la Inhibicion del Gen Profibrotico y la Expresion de Proteinas

• Published in: International journal of morphology 2024-03, Vol.42 (2), p.249
• Main Authors: Alshahrani, Mohammad Y, Ebrahim, Hasnaa A, Almasabi, Faris, Suliman, Muath, A-Elgadir, Thoraya M.E, Ellatif, Mohamed Abd, Alzamil, Norah M, Amri, Fahad S. Al, Al-Ani, Bahjat
• Format: Article
• Language: Spanish
• ISSN: 0717-9367

The response of the immune system to harmful stimuli leads to inflammation, and the adverse effects of the toxic hepatitis chemical, thioacetamide (TAA) on the human body are well documented. This article investigated the degree of protection provided by the combined pleotropic drug, metformin (Met) and the plant polyphenolic and the antiinflammatory compound, resveratrol (Res) on liver tissue exposed to TAA possibly via the inhibition of the inflammatory cytokine, tumor necrosis factor-[alpha] (TNF-[alpha]) / mammalian target of rapamycin (mTOR) axis-mediated liver fibrosis, as well as amelioration of profibrotic gene and protein expression. Rats were either given TAA (200 mg/kg via intraperitoneal injection) for 8 weeks beginning at the third week (experimental group) or received during the first two weeks of the experiment combined doses of metformin (200 mg/kg) and resveratrol (20 mg/kg) and continued receiving these agents and TAA until experiment completion at week 10 (treated group). A considerable damage to hepatic tissue in the experimental rats was observed as revealed by tissue collagen deposition in the portal area of the liver and a substantial increase (p