Analysis of Blood Culture Results and Antibiotic Sensitivities in Adult Patients Applying to a Training and Research Hospital in Istanbul/Istanbul'da Bir Egitim ve Arastirma Hastanesine Basvuran Eriskin Hastalarin Kan Kulturu Sonuclari ve Antibiyotik Duyarliliklarinin Analizi

• Published in: Boğaziçi tıp dergisi 2024-03, Vol.11 (1), p.7
• Main Authors: Dogan, Fatma Sari, Akoglu, Ebru Unal, Ozturk, Tuba Cimilli
• Format: Article
• Language: Turkish
• Subjects: Aminoglycosides; Analysis; Blood; Ciprofloxacin; Drug resistance in microorganisms; Infection; Medical examination; Methicillin; Mortality; Staphylococcus aureus infections
• ISSN: 2149-0287; 2149-0287
• DOI: 10.14744/bmj.2024.72623

Objectives: Sepsis is a life-threatening condition caused by microorganisms entering the bloodstream and spreading very rapidly. In sepsis guidelines, starting early antibiotic treatment is one of the main steps of treatment. Therefore, it is necessary to know the antibiotics to which the agents are susceptible. Our study aimed to determine the antibiotic susceptibility and resistance of microorganisms grown in blood cultures obtained from patients admitted to the emergency department of our hospital and treated in the inpatient ward or intensive care unit. Methods: The blood cultures in our hospital in the 1-year period between 2018 and 2019 were analyzed retrospectively. The age and gender of the patients from whom the blood cultures were obtained, the microorganisms grown, and their antibiotic susceptibility/resistance were recorded and analyzed statistically. Results: A total of 1232 blood cultures were included in the study, and growth was observed in 182 blood cultures. Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli, Enterococcus faecalis, and Acinetobacter baumannii were isolated most frequently. The antibiotics to which staphylococci were most susceptible were trimethoprim- sulfamethoxazole, vancomycin, and gentamicin, while the highest resistance was found to ertapenem and penicillin. Methicillin-resistant coagulase-negative Staphylococcus (MRCNS) was 54.1%, and methicillin-resistant Staphylococcus aureus (MRSA) was 28%. For Escherichia coli, ceftriaxone resistance was 72%, ciprofloxacin resistance was 68.4%, while 82.4% were susceptible to gentamicin, and 100% to carbapenems. Multidrug resistance was 61%. Conclusion: In our study, Staphylococcus epidermidis, Staphylococcus aureus, Escherichia coli, Enterococcus faecalis, and Acinetobacter baumannii were isolated most frequently from blood cultures, respectively. Escherichia coli was highly resistant to ciprofloxacin and ceftriaxone but susceptible to aminoglycosides and carbapenems. We also found that multidrug resistance was quite high. Early initiation of appropriate antibiotics in the treatment of sepsis and bacteremia reduces mortality. Therefore, it is important to determine the most frequently isolated pathogens and their antibiotic susceptibility and resistance status. Keywords: Antibiogram; Antibiotic resistance; Blood culture; Multidrug resistance; Sepsis. Amac: Mikroorganizmalarin kana karisip cok hizli bir sekilde yayilarak olusturdugu ve hayati tehdit eden durum,