Polyphenols from IMaackia amurensis/I Heartwood Protect Neuronal Cells from Oxidative Stress and Prevent Herpetic Infection

Here, we continued the investigation of anti-HSV-1 activity and neuroprotective potential of 14 polyphenolic compounds isolated from Maackia amurensis heartwood. We determined the absolute configurations of asymmetric centers in scirpusin A (13) and maackiazin (10) as 7R,8R and 1″S,2″S, respectively...

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Published in:International journal of molecular sciences 2024-04, Vol.25 (8)
Main Authors: Tarbeeva, Darya V, Pislyagin, Evgeny A, Menchinskaya, Ekaterina S, Berdyshev, Dmitrii V, Krylova, Natalya V, Iunikhina, Olga V, Kalinovskiy, Anatoliy I, Shchelkanov, Mikhail Y, Mishchenko, Natalia P, Aminin, Dmitry L, Fedoreyev, Sergey A
Format: Article
Language:English
Subjects:
Antiviral agents
Bioflavonoids
Flavones
Flavonoids
Health aspects
Infection
Infection control
Neurons
Neurophysiology
Polyphenols
Prevention
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Summary:Here, we continued the investigation of anti-HSV-1 activity and neuroprotective potential of 14 polyphenolic compounds isolated from Maackia amurensis heartwood. We determined the absolute configurations of asymmetric centers in scirpusin A (13) and maackiazin (10) as 7R,8R and 1″S,2″S, respectively. We showed that dimeric stilbens maackin (9) and scirpusin A (13) possessed the highest anti-HSV-1 activity among polyphenols 1–14. We also studied the effect of polyphenols 9 and 13 on the early stages of HSV-1 infection. Direct interaction with the virus (virucidal activity) was the main mechanism of the antiviral activity of these compounds. The neuroprotective potential of polyphenolic compounds from M. amurensis was studied using models of 6-hydroxydopamine (6-OHDA)-and paraquat (PQ)-induced neurotoxicity. A dimeric stilbene scirpusin A (13) and a flavonoid liquiritigenin (6) were shown to be the most active compounds among the tested polyphenols. These compounds significantly increased the viability of 6-OHDA-and PQ-treated Neuro-2a cells, elevated mitochondrial membrane potential and reduced the intracellular ROS level. We also found that scirpusin A (13), liquiritigenin (6) and retusin (3) considerably increased the percentage of live Neuro-2a cells and decreased the number of early apoptotic cells. Scirpusin A (13) was the most promising compound possessing both anti-HSV-1 activity and neuroprotective potential.
ISSN:1422-0067
DOI:10.3390/ijms25084142