SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL STUDIES OF CIPROFLOXACI-IMINES AND THEIR COMPLEXES WITH OXOZIRCONIUM

We synthesized and characterized ciprofloxacin-imine complexes, generated from ciprofloxacin and either 4-nitro-1,2-phenylenediamine (N[O.sub.2]PD) or 1,3-propanediamine (PD), in conjunction with zirconyl nitrate dihydrate, sodium molybdate dihydrate, and sodium tungstate dihydrate. Characterization...

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Bibliographic Details
Published in:Bulletin of the Chemical Society of Ethiopia 2024-04, Vol.38 (4), p.949
Main Authors: Al-Assafe, Amaal Y, Al-Quaba, Rana A.S
Format: Article
Language:English
Subjects:
Ciprofloxacin
Schiff bases
Staphylococcus aureus
Tungsten compounds
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Summary:We synthesized and characterized ciprofloxacin-imine complexes, generated from ciprofloxacin and either 4-nitro-1,2-phenylenediamine (N[O.sub.2]PD) or 1,3-propanediamine (PD), in conjunction with zirconyl nitrate dihydrate, sodium molybdate dihydrate, and sodium tungstate dihydrate. Characterization involved numerous analytical methods, containing melting point determination, conductance dimensions, elemental analysis (CHN), metal content determination (%), infrared, electronic spectra, nuclear magnetic resonance, and mass spectrometry. Our findings reveal that the ligand as functions a tetra-dentate chelate binding to metal ions via azomethine and deprotonated carboxylate group. Additionally, the complexes and ligands were tested in contradiction of two types of bacteria (Staphylococcus aureus, Bacillus subtilis) and all prepared compounds showed good spectrum activity. KEY WORDS: 4-Nitro-1,2-phenylenediamine, Ciprofloxacin-imine, In-vitro antimicrobial activity, Zr complexes
ISSN:1011-3924
DOI:10.4314/bcse.v38i4.11