Etomidate alleviates ovarian ischemia-reperfusion injury in rats/Etomidat ratlarda over iskemi-reperfuzyon hasarini hafifletir

BACKGROUND: This study investigates the protective effects of etomidate against oxidative damage in an experimental model of ovarian ischemia-reperfusion injury. METHODS: A total of 24 female rats were randomized into three groups. Group I served as the control. Group 2 underwent an ovarian torsion/...

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Published in:Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES 2024-06, Vol.30 (6), p.375
Main Authors: Kolukcu, Vildan, Balta, Mehtap Gurler, Tapar, Hakan, Karaman, Tugba, Karaman, Serkan, Unsal, Velid, Gevrek, Fikret, Katar, Muzaffer
Format: Article
Language:English
Subjects:
Analysis
Antioxidants
Etomidate
Inflammation
Interleukins
Lipid peroxidation
Peroxidase
Reperfusion injury
Superoxide
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Summary:BACKGROUND: This study investigates the protective effects of etomidate against oxidative damage in an experimental model of ovarian ischemia-reperfusion injury. METHODS: A total of 24 female rats were randomized into three groups. Group I served as the control. Group 2 underwent an ovarian torsion/detorsion procedure. Group 3 underwent similar procedures as Group 2; additionally, 4 mg/kg of etomidate was administered intraperitoneally 30 minutes before ovarian detorsion. Blood samples were analyzed for lipid peroxidation, pro-inflammatory cytokine levels, and antioxidant enzyme activity.Furthermore, histopathological scoring was performed to evaluate tissue damage in the ovaries. RESULTS: Biochemical analysis of blood samples revealed reductions in pro-inflammatory cytokines, including interleukin-I Beta (IL-1[beta]), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-[alpha]), in Group 3 compared to Group 2 (p=0.005, p=0.016, and p
ISSN:1306-696X
DOI:10.14744/tjtes.2024.27388